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Hindi Research Article
Correlations of Oxidized Low Density Lipoprotein with Insulin, Leptin and Risk of Cardiovascular Disease in a group of Diabetic Obese Tunisian Women
| Fethi Ben Slama1*, Wala Gaaloul Helali2, Faika Ben Mami3, Mohamed Chiheb Ben Rayana3, Omrane Belhadj4 and Hajer Aounallah Skhiri1 | |
| 1National Institute of Public Health, Tunisia | |
| 2Faculty of Pharmacy of Monastir, Tunisia | |
| 3National Institute of Nutrition, Tunisia | |
| 4Laboratory of Biochemistry and Biotechnology, Faculty of Sciences of Tunisia, Tunisia | |
| Corresponding Author : | Fethi Ben Slama National Institute of Public Health, Tunisia Tel: (216) 97 861 981 E-mail: benslamafethi@yahoo.fr |
| Received: September 29, 2015 Accepted: October 26, 2015 Published: October 30, 2015 | |
| Citation:Slama FB, Helali WG, Mami FB, Rayana MCB, Belhadj O, et al. (2015) Correlations of Oxidized Low Density Lipoprotein with Insulin, Leptin and Risk of Cardiovascular Disease in a group of Diabetic Obese Tunisian Women. J Obes Weight Loss Ther 5:279. doi: 10.4172/2165-7904.1000279 | |
| Copyright: ©2015 Slama FB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
| Related article at Pubmed, Scholar Google | |
Abstract
At the obese diabetic ones, there’s a disturbance of lipid parameters from where the installation of an insulin resistance responsible for the development of non-insulin-dependent diabetes.
Objectives: Our objectives were to evaluate the levels of insulin, leptin and oxidized LDL, and to search the link which could exist between these parameters and obesity represented by the body mass index (BMI >30 kg/m2).
Methods: We proportioned the rate in total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL, cholesterol HDL and oxidized LDL at 53 obese women diabetic not carrying pathologies other than the diabetes type 2 and obesity compared to 21 witnesses who theirs are paired according to the age.
Results: Our results shows that levels of total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL and oxidized LDL were higher in obese women with non-insulin-dependent diabetes mellitus compared with control group. Moreover a positive and significant correlation between body mass index and blood glucose (r=0.408, p=0.002), leptin (r=0.436, p=0.001), insulin (r=0.403, p=0.003), cholesterol LDL (r=0.365, p=0.007) and oxidized LDL (r=0.632, p<0.001) and a negative and significant correlation between body mass index and cholesterol HDL (r=-0.345, p=0.011) were observed. An analysis multivariate linear regression showed that leptin, cholesterol LDL and oxidized LDL were directly correlated with body mass index. Different biochemical parameters were correlated between each other and with body mass index. Leptin, cholesterol LDL and oxidized LDL were directly correlated to obesity. Body mass index is a strong predictor of leptin circulating levels, cholesterol LDL and oxidized LDL.
Conclusion: Body mass index can predict leptin, cholesterol LDL and oxidized LDL circulating levels. So these parameters involved in diabetes mellitus and cardiovascular diseases can be controlling by regulation of body weight and prevention of obesity.
