alexa Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha

Oxenkrug GF1*, Turski WA2, Zgrajka W3, Weinstock JV4, Ruthazer R5 and Summergrad P1
1 Department of Psychiatry, Tufts Medical Center/Tufts University, Boston, MA, USA
2 Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.
3 Department of Toxicology, Institute of Rural Health, Lublin, Poland.
4 Division of Gastroenterology/Hepatology, Tufts Medical Center/Tufts University, Boston, MA, USA.
5 Institute for Clinical Research and Health Policy Studies, Tufts Medical Center/Tufts University, Boston, MA, USA
Corresponding Author : Oxenkrug GF
Psychiatry and Inflammation Program
Department of Psychiatry
Tufts University/Tufts Medical Center
Boston, MA, USA
E-mail: [email protected]
Received January 24, 2014; Accepted February 22, 2014; Published February 25, 2014
Citation: Oxenkrug GF, Turski WA, Zgrajka W, Weinstock JV, Ruthazer R, et al. (2014) Disturbances of Tryptophan Metabolism and Risk of Depression in HCV Patients Treated with IFN-Alpha. J Infect Dis Ther 2:131. doi:10.4172/2332-0877.1000131
Copyright: © 2014 Oxenkrug GF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google

Abstract

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus (HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might contribute to development of IFN-alpha–associated depression due to IFN-alpha-induced activation of indoleamine 2,3-dioxygenase (IDO), a rate-limiting enzyme of TRP– kynurenine (KYN) metabolism. The increased frequency of high producer (T) allele of IFN-gamma (IFNG) (+874) gene, that encodes IFNG production, in depressed patients suggested that increased IDO activity might be a risk factor for depression. The present study assessed KYN/TRP ratio (KTR) as a marker of IDO activity in American Caucasian HCV patients awaiting IFN-alpha treatment. KTR did not differ between 43 patients who did and 37 patients who did not develop depression. TRP concentrations were higher in patients who experienced depression. Odds of development of depression increased with elevation of serum TRP levels from 33% (TRP levels <12000 pmol/ml) to 68% (TRP levels > 16000 pmol/ml). Elevated serum TRP may reflect the impairment of TRP conversion into serotonin in agreement with suggested link between serotonin deficiency and depression. Up-regulation of IDO might be an additional risk factor of IFN-alpha– associated depression. Future studies shall explore the causes of elevated serum TRP in relation to IFN-alpha–associated depression.

Keywords

Recommended Conferences
Share This Page
Top