alexa Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity

Arisaka O*, Ichikawa G, Koyama S, Shimura N, Imataka G, Kurosawa H and Nitta A
Department of Pediatrics, Dokkyo Medical University School of Medicine Mibu, Shimotsuga-gun, Tochigi-ken, 321-0293 Japan
*Corresponding Author : Arisaka O
Department of Pediatrics
Dokkyo Medical University School of Medicine
Mibu, Shimotsuga-gun, Tochigi-ken, 321-0293, Japan
Fax: +81 (0) 282 86 7521
Tel: +81 (0)282 86 1111
E-mail: [email protected]
Received: February 16, 2016 Accepted: February 25, 2016 Published: February 29, 2016
Citation: Arisaka O, Ichikawa G, Koyama S, Shimura N, Imataka G et al. (2016) Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity. J Obes Weight Loss Ther 6:301. doi:10.4172/2165-7904.1000301
Copyright: © 2016 Arisaka O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Aim: The adiposity rebound (AR) corresponds to the second rise in the body mass index (BMI) curve that occurs between ages 5 and 7 years. The goal of this study was to determine whether age at AR is related to the presence at 12 years old of small dense low-density lipoprotein (SDLDL), an atherogenic lipoprotein produced as a metabolic consequence of AR. Methods: A longitudinal population-based prospective study was performed in 215 children. Serial measurements of BMI were conducted at ages 1, 1.5, 2 and yearly thereafter until 12, based on which age at AR was calculated. The subjects were divided into 5 groups according to age at AR of ≤4, 5, 6, 7 and ≥8 years. Plasma lipids and SDLDL were measured at 12 years of age. SDLDL (LDL particle size <25.5 nm) was determined by nondenaturing 2-16% gradient gel electrophoresis. Results: The prevalences of SDLDL were 15.0% in children with age at AR ≤4 y, 8.1% in those with age at AR 5 y, and 0% in all other groups (AR at ≥6 years). An earlier AR was significantly associated with higher BMI, increased plasma triglyceride (p < 0.05), increased atherogenic index (p < 0.05), and decreased HDL-cholesterol (p < 0.05) at 12 years of age. Conclusion: Children with AR before 4 years old showed a high prevalence of atherogenic SDLDL, indicating a predisposition for future cardiovascular disease.

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