alexa Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity

Arisaka O*, Ichikawa G, Koyama S, Shimura N, Imataka G, Kurosawa H and Nitta A
Department of Pediatrics, Dokkyo Medical University School of Medicine Mibu, Shimotsuga-gun, Tochigi-ken, 321-0293 Japan
*Corresponding Author : Arisaka O
Department of Pediatrics
Dokkyo Medical University School of Medicine
Mibu, Shimotsuga-gun, Tochigi-ken, 321-0293, Japan
Fax: +81 (0) 282 86 7521
Tel: +81 (0)282 86 1111
E-mail: [email protected]
Received: February 16, 2016 Accepted: February 25, 2016 Published: February 29, 2016
Citation: Arisaka O, Ichikawa G, Koyama S, Shimura N, Imataka G et al. (2016) Early Adiposity Rebound and Small Dense Low-Density Lipoprotein in Childhood Obesity. J Obes Weight Loss Ther 6:301. doi:10.4172/2165-7904.1000301
Copyright: © 2016 Arisaka O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: The adiposity rebound (AR) corresponds to the second rise in the body mass index (BMI) curve that occurs between ages 5 and 7 years. The goal of this study was to determine whether age at AR is related to the presence at 12 years old of small dense low-density lipoprotein (SDLDL), an atherogenic lipoprotein produced as a metabolic consequence of AR. Methods: A longitudinal population-based prospective study was performed in 215 children. Serial measurements of BMI were conducted at ages 1, 1.5, 2 and yearly thereafter until 12, based on which age at AR was calculated. The subjects were divided into 5 groups according to age at AR of ≤4, 5, 6, 7 and ≥8 years. Plasma lipids and SDLDL were measured at 12 years of age. SDLDL (LDL particle size <25.5 nm) was determined by nondenaturing 2-16% gradient gel electrophoresis. Results: The prevalences of SDLDL were 15.0% in children with age at AR ≤4 y, 8.1% in those with age at AR 5 y, and 0% in all other groups (AR at ≥6 years). An earlier AR was significantly associated with higher BMI, increased plasma triglyceride (p < 0.05), increased atherogenic index (p < 0.05), and decreased HDL-cholesterol (p < 0.05) at 12 years of age. Conclusion: Children with AR before 4 years old showed a high prevalence of atherogenic SDLDL, indicating a predisposition for future cardiovascular disease.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_phys[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version