alexa Early Outcome of Prostate Intensity Modulated Radiation Therapy (IMRT) Incorporating a Simultaneous Intra-Prostatic MRI Directed Boost | OMICS International | Abstract
ISSN:2167-7964

OMICS Journal of Radiology
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Research Article

Early Outcome of Prostate Intensity Modulated Radiation Therapy (IMRT) Incorporating a Simultaneous Intra-Prostatic MRI Directed Boost

Michael H Schild, Steven E Schild*, William W Wong, Sujay A Vora, Alvin C Silva, Annelise M Silva, Thomas B Daniels and Sameer R Keole
Department of Radiation Oncology, Mayo Clinic Arizona, Scottsdale 85259, USA
Corresponding Author : Steven E Schild
Mayo Clinic, 13400 E. Shea Blvd
Scottsdale, AZ 85259, USA
Tel: 480-301-8000
Fax: 480-342-3972
E-mail: [email protected]
Received October 20, 2014; Accepted November 17, 2014; Published November 20, 2014
Citation: Schild SE, Schild MH, Wong WW, Vora SA, Silva AC, et al. (2014) Early Outcome of Prostate Intensity Modulated Radiation Therapy (IMRT) Incorporating a Simultaneous Intra-Prostatic MRI Directed Boost. OMICS J Radiol 3:170. doi: 10.4172/2167-7964.1000170
Copyright: © 2014 Schild SE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study assessed the feasibility and outcomes of treating prostate cancer with intensity modulated radiotherapy (IMRT) incorporating a Magnetic Resonance Imaging (MRI) directed boost. Seventy-eight men received IMRT for localized prostate cancer. The entire prostate received 77.4Gy in 43 fractions and simultaneous intra-prostatic boosts (SIB) of 83Gy were administered to increase the dose to the MRI identified malignancy. In 16 (21%) patients, the MRI didn’t detect a neoplasm and these patients received an SIB of 81Gy to the posterior prostate. Androgen Deprivation Therapy (ADT) was also administered to 32 (41%) patients. The 3-year rates of biochemical control, local control, distant control, and survival were 92%, 98%, 95%, and 95% respectively. While grade 1-2 toxicities were common, there were only 2 patients who suffered grade 3 toxicity. These patients developed strictures which were dilated resulting in improvement in symptoms such that both had grade 1-2 toxicity at last follow up examination. The results of this program of IMRT incorporating a MRI directed intra-prostatic boost suggest this technique is feasible and well tolerated. This technique appears to shift the therapeutic index favorably by boosting the malignancy to the highest dose without increasing the doses administered to the bladder and rectum.

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