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Effects of Fish Oil on Cytokines, Glycemic Control, Blood Pressure, and Serum Lipids in Patients with Type 2 Diabetes Mellitus | OMICS International | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Effects of Fish Oil on Cytokines, Glycemic Control, Blood Pressure, and Serum Lipids in Patients with Type 2 Diabetes Mellitus

Reza Rastmanesh1*, Afrooz Javidi2, Fourough A Taleban1, Masood Kimaigar1 and Yadollah Mehrabi3
1Faculty of Nutrition and Food Technology, Department of Clinical Nutrition & Dietetics, Shahid Beheshti University of Medical Sciences (SBUMS), Tehran, Iran
2Shiriz Medical University, Faculty of Nutrition, Shiraz, Iran
3Department of Health and Community Medicine, Shaheed Beheshti University of Medical Sciences (SBUMS), Tehran, Iran
Corresponding Author : Reza Rastmanesh
Faculty of Nutrition and Food Technology
Department of Clinical Nutrition & Dietetics
Shahid Beheshti University of Medical Sciences (SBUMS), Tehran, Iran
Tel: +98 21) 22 357484
E-mail: [email protected]
Received September 06, 2013; Accepted October 24, 2013; Published October 28, 2013
Citation: Rastmanesh R, Javidi A, Taleban FA, Kimaigar M, Mehrabi Y (2013) Effects of Fish Oil on Cytokines, Glycemic Control, Blood Pressure, and Serum Lipids in Patients with Type 2 Diabetes Mellitus. J Obes Weight Loss Ther 3:197. doi:10.4172/2165-7904.1000197
Copyright: © 2013 Rastmanesh R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: We examined the ability of dietary fish oil to suppress markers of inflammation and consequent effect(s) on serum fasting glycemia, lipids, and blood pressure in patients with T2DM. Design: Correlations between serum fasting interleukin-6, Interleukin-1β (IL-1β), TNF-α (TNF-α), C-reactive Protein (CRP), and sialic acid, with indices of glycemia, insulin, and lipids were determined in 26 patients with T2DM at baseline, 4 weeks and 8 weeks after supplementation with fish oil (3 g/d) to analyse possible correlations between markers of inflammation and indices of glycemia. Results: There were no significant correlations between markers of inflammation with indices of glycemia at baseline, 4 weeks and 8 weeks after fish oils supplementation. Serum CRP concentrations were negatively correlated with fasting serum LDL, and with Cholesterol (r=-0.424, P<0.04; r=- 0.447, P<0.03, respectively). Fasting IL-1 β concentrations were positively correlated with fasting LDL, and with cholesterol at week 4 (r=0.482, P<0.02; r=0.469, P<0.02, respectively). There were no significant correlations between serum lipids with markers of inflammation at the end of intervention. There were no significant changes in serum fasting insulin, and glucose concentrations at the end of the intervention. Conclusions: A moderate dose of fish oil did not lead to deleterious effects on glycemic control in patients with T2DM, with preserved triacyglycerol-lowering capacities.

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