Abstract

Lyme disease is a rapidly spreading infectious disease that is widespread in large parts of temperate Eurasia and North America. About 80% of patients have an erythema migrans rash, which can look like the traditional target bull'seye lesion or unrelated lesions. This rash is linked to early infection and is present in a variety of patients. Methods. The general public's capacity to recognise different erythema migrans manifestations from non-Lyme rashes was tested through a survey. By N-deacetylating chitin with a strong alkali, chitosan, a non-toxic, biocompatible, and biodegradable polymer, is created. As a bilayer skin-regenerating template, chitosan can serve as a scaffold for regeneration. Integra is a two-layer skin regeneration system made of a crosslinked fibre matrix that serves as a scaffold for renewing dermal skin cells. The "gold standard" for short-term treatment of clean burn wounds is human skin allografts (HSAs).Objectives. This study aimed to evaluate the in-vivo, preclinical biocompatibility of the Integra, HSA, and Chitosan skin-regenerating templates (SRT). Methods. To implant test materials, paravertebral subcutaneous niches were developed. After 4, 7, 14, 21, and 28 days, implants were removed.