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ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
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Research Article

Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology

Renati Damodar1*, Babji Movva1, Mallikarjun PN1, Chaitanya Pasumarthy2, Nishanth Kona3 and Varsha PV4
1Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, India
2Mother Teresa College of Pharmacy, Ghatkesar, Hyderabad, India
3Department of Pharmaceutics, Sree Siddaganga College Pharmacy, Tumkur, Karnataka, India
4Department of Biotechnology, GITAM University, Visakhapatnam, Andhra Pradesh, India
Corresponding Author : Renati Damodar
Department of Pharmaceutics
Vignan Institute of Pharmaceutical Technology
Visakhapatnam, Andhra Pradesh, India
Tel: +918500932050
E-mail: [email protected]
Received May 27, 2014; Accepted July 28, 2014; Published July 31, 2014
Citation: Damodar R, Movva B, Mallikarjun PN, Pasumarthy C, Kona N, et al. (2014) Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology. J Mol Pharm Org Process Res 2:116. doi: 10.4172/2329-9053.1000116
Copyright: © 2014 Damodar R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Research has done to prepare Diclofenac Sodium quick dissolving tablets by Hole technology. Once these quick dissolving tablets contact with gastro enteric fluids, the fluid can enter the hole within the tablet and immediate breaking of the tablet goes to take place. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. The ready FDTs were subjected to numerous pre and post formulation studies. Its disintegration and dissolution rates were compared with the management formulation (without hole). In-vitro drug release of FDTs (DH6) showed virtually 100.92% of the drug was discharged at sixth minute, whereas the management formulation D12 shows the 99% drug release at 20th minute. Overall, this method is novel and most helpful for formulation into quick dissolving tablets.


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