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ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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Review Article

Functionalized Biomaterials - Oxygen Releasing Scaffolds

Jeong Ok Lim1,2*, Jeung Soo Huh1, Syed Izhar Haider Abdi1,2, Sing Muk Ng3 and James J Yoo4

1Kyungpook National University, Daegu 700-412, Republic of Korea

2Biomedical Research Institute, Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu 700-412, Republic of Korea

3School of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus, Jalan Simpang Tiga, 93350, Kuching, Malaysia

4Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC USA

Corresponding Author:
Jeong Ok Lim
Department of Biomedical Science
Kyungpook National University, Daegu 700-412, Republic of Korea
Tel: 82534205447
E-mail: [email protected]

Received date:: April 25, 2015; Accepted date:: May 28, 2015; Published date:: June 04, 2015

Citation: Lim JO, Huh JS, Abdi SIH, Ng SM, Yoo JJ (2015) Functionalized Biomaterials - Oxygen Releasing Scaffolds. J Biotechnol Biomater 5:182. doi:10.4172/2155-952X.1000182

Copyright: © 2015 Lim JO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The advancement in tissue engineering has reached a considerably high level with major achievements, especially in mimicking the nature in terms of morphology, structure, functionality and mechanical strength. Nonetheless, the current technology still fails to deliver the urgent need in producing construct of larger volume such as organs, which will be more effective in tackling chronic diseases related to organ failure. One of the main causes identified is due to the serious necrosis that occurs as a result of the deficient of oxygen due to its low dissolution and diffusion in thick tissue matrices. The rate of vascularization is far too low compared to the differentiation rate of the cells. In order to sustain the survival of cells before the establishment of blood vessel, an alternative supply of external oxygen to the cells will be of advantage. Current trend has seen to be moving towards this direction, and the external supply can be obtained from tissue scaffolds. This approach is made possible by functionalizing biomaterials with well controlled oxygen producing mechanism. This review concentrates on such efforts and discusses some of the insights that are related in developing functionalized biomaterial scaffolds with the intention to adequately supply oxygen for tissue engineering purpose.

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