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Ghrelin Plasma Levels and Gastric Tissues Expression in Patients Submitted to Laparoscopic Sleeve Gastrectomy as Primary or Revisional Weight Loss Procedure
| Claudio Di Cristofano1, Caterina Chiappetta1, Francesco De Angelis2, Natale Porta1, Jessica Cacciotti1, Eugenio Lendaro1, Vincenzo Petrozza1, Carlo Della Rocca1* and Gianfranco Silecchia2 |
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| 1 UOC of Pathology, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Polo Pontino, I.C.O.T, Latina, Italy | |
| 2 UOC of Surgery, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Polo Pontino, I.C.O.T, Latina, Italy | |
| Corresponding Author : | Carlo Della Rocca, MD UOC of Pathology Department of Medical-Surgical Sciences and Bio-Technologies Sapienza University of Rome Polo Pontino, I.C.O.T, Latina Corso della Repubblica 79, Italy Tel: 0773-6513411 E-mail: carlo.dellarocca@uniroma1.it |
| Received April 29, 2014; Accepted May 21, 2014; Published May 26, 2014 | |
| Citation: Cristofano CD, Chiappetta C, Angelis FD, Porta N, Cacciotti J, et al. (2014) Ghrelin Plasma Levels and Gastric Tissues Expression in Patients Submitted to Laparoscopic Sleeve Gastrectomy as Primary or Revisional WeightLoss Procedure. J Obes Weight Loss Ther 4:215. doi:10.4172/2165-7904.1000215 | |
| Copyright: © 2014 Cristofano CD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Introduction: Ghrelin (Ghr) plays a role in the regulation of food intake and Laparoscopic Sleeve gastrectomy (LSG) is used for treatment of morbid obesity (MO) and after this the expression of ghrelin could be modulate. The aim of present study was to analyze the expression of ghr in three areas of resected stomach specimens from MO patients and co rrelate these data with plasmatic ghrelin levels before andafter surgery. Materials and Methods: 36 morbidly obese patients (17%, 6/36 with Type 2 Diabetes) were subjected to LSG and tissue samples were obtained from the fundus, body, prepyloric of the resected stomach. For mRNA and protein expression analysis. Blood samples were collected before and 1 month after surgery to evaluate the plasmatic ghrelin levels. Results: Ghrelin protein expression was higher in the fundus than in the other areas. T2DM patients showed a lower basal ghrelin plasma level compared with non-diabetic patients but they showed a high percentage of positive cells in the stomach. Was not observed a statistically difference in plasmatic, mRNA and protein expression of ghrelin between primary LSG patients and in revisional LSG group. Conclusion: Ghrelin fundal mucosal expression was comparable in primary and revisional LSG. Diabetic patients showed a compensatory higher protein mucosal expression probably to balance lower plasma Ghrelin level. Further studies will elucidate the clinical relevance of those preliminary data.
