Abstract

This collection of articles addresses critical challenges in biosecurity and biodefense, focusing on dual-use research, bioterrorism preparedness, and emerging biotechnologies. It highlights the need for robust governance frameworks, ethical oversight, and international collaboration to prevent the misuse of life sciences for weaponization. Key themes include the role of biosensors in detection, the strengthening of the Biological Weapons Convention, and unified approaches to pandemic preparedness. The discussions emphasize mitigating risks from synthetic biology and gene-editing technologies like CRISPR, alongside integrating biological intelligence for comprehensive national biosecurity strategies. A One Health approach is advocated for addressing both natural and deliberate biological threats.