Hyaluronic Acid and Derivatives for Tissue Engineering.Farid Menaa1, Abder Menaa2 and Bouzid Menaa1*
- Corresponding Author:
- Dr. B Menaa
Fluorotronics, Inc, Departments of Life Sciences
Chemistry and Nanobiotechnology, 2453 Cades Way
Bldg C, San Diego, CA 92081, USA
E-mail: [email protected], [email protected]
Received date: July 14, 2011; Accepted date: November 14, 2011; Published date: November 16, 2011
Citation: Menaa F, Menaa A, Menaa B (2011) Hyaluronic Acid and Derivatives for Tissue Engineering. J Biotechnol Biomaterial S3:001. doi:10.4172/2155-952X. S3-001
Copyright: © 2011 Menaa F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Among the protein-based hydrogel-forming polymers, various salts of hyaluronic acid (HA), aka hyaluronan or sodium hyaluronate, are used to prepare tissue-engineering. HA is a natural occurring glycosaminoglycan, a polysaccharide of high molecular weight which displays interesting viscoelastic properties. Among other organisms, HA is omnipresent in the human body, occurring in almost all biological fluids and tissues, although the highest amounts of HA are found in the extracellular matrix of soft connective tissues. HA is synthesized in a unique manner by a family of hyaluronan synthases and degraded by hyaluronidases and, exerts pleiotropic biological functions such as tissue repair and tissue regeneration. The excellent biocompatibility and biodegradability of HAderived hydrogels make them ideal materials for tissue engineering. Nevertheless, because of their hydrophilic nature, further modification with adhesion-mediating peptides is required to allow sufficient cell attachment. Hence, several methods of chemical cross-linking using different linkers have been investigated to improve the mechanical properties of those materials for long-term applications in the biomedical field. This manuscript provide an overview of HA and derivatives used as biomaterial scaffold for theranostic medicine.