alexa <em>In vivo</em> Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Research Article

In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation

Safila Naveed1,3*, Najma Sultana2, Saeed Arayne M2, Rakhshinda Siddiqui4 and Moona Mehboob4
1Faculty of Pharmacy, Jinnah University for Women Karachi, Pakistan
2United Biotechnologies, Karachi, Pakistan
3Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan
4CHK, Dow University Health Sciences, Karachi, Pakistan
Corresponding Author : Safila Naveed
Research Institute of Pharmaceutical Sciences
Department of Pharmaceutical Chemistry
Faculty of Pharmacy, University of Karachi, Pakistan
Tel: +0092-03002621917
Fax: +0092-36440171
E-mail: [email protected], [email protected]
Received February 18, 2013; Accepted March 27, 2013; Published March 29, 2013
Citation: Naveed S, Sultana N, Saeed Arayne M, Siddiqui R, Mehboob M (2013) In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation. Clinic Pharmacol Biopharm 2:108. doi:10.4172/2167-065X.1000108
Copyright: © 2013 Hari Krishna E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Both antihypertensive and non steroidal anti-inflammatory drugs are frequently prescribed together since hypertension and co-existing musculoskeletal problems are two of the frequent conditions. In vivo interaction studies of ACE inhibitors (enalapril, captopril and lisinopril) were carried out with commonly used NSAIDs (diclofenac sodium and mefenamic acid) in carrageenan induced inflammation in rats (CII) to check the anti-inflammatory response of NSAIDs in such cases. Edema rate and percentage reduction were calculated and data was analyzed by one way analysis of variance using SPSS INC. software. Tukey’s post-hoc test was conducted to determine group means differences taking significant level p<0.05 and p<0.005 highly significant.


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