Influence of Bile Salts as Excipients in Ranitidine, Aminophylline and Phenobarbital Tablets on Dissolution Rate
- *Corresponding Author:
- Marta Pocuca
Medical Faculty Novi Sad
Department of Pharmacology
Toxicology and Clinical Pharmacology
University of Novi Sad
Hajduk Veljkova 3, 21000 Novi Sad, Republic of Serbia
E-mail: [email protected]
Received Date: May 22, 2017; Accepted Date: May 30, 2017; Published Date: May 31, 2017
Citation: Pocuca M, Cvejic J, Vukmirovic S, Stilinovic N, Kuhajda K, et al. (2017) Influence of Bile Salts as Excipients in Ranitidine, Aminophylline and Phenobarbital Tablets on Dissolution Rate. Clin Pharmacol Biopharm 6:171. doi: 10.4172/2167-065X.1000171
Copyright: © 2017 Pocuca M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim: The aim of this study is to investigate the influence of bile salts, sodium cholate, sodium 12-ketocholate and sodium dehydrocholate, as excipients in ranitidine, aminophylline and phenobarbital tablets on dissolution rate.
Methods: Four groups of tablets (control without bile salts and three investigational groups containing different bile salts) were prepared for three different drug substances: ranitidine, aminophylline and phenobarbital. Dissolution rate was measured.
Results: Dissolution rate is increased significantly in all investigational groups comparing to the control group in all three drug substances.
Discussion: Presented results are very favourable and encouraging in case of dissolution enhancing and should be further investigated, especially in drug substances that are classified in class II and IV as per Biopharmaceutical Classification System (BCS) classification.
Conclusion: Bile acid salts are very promising excipients, proven to act as surfactants and as lubricants. Running title: Bile salts as excipients in ranitidine, aminophylline and phenobarbital tablets.