Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats
Received Date: Dec 22, 2017 / Accepted Date: Jan 25, 2018 / Published Date: Feb 10, 2018
We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.
Keywords: Regulatory peptides; ACTH4-7; Glyprolines; Pain; Aggression
Citation: Severyanova LA, Plotnikov DV (2018) Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats. J Bioterror Biodef 9: 160. Doi: 10.4172/2157-2526.1000160
Copyright: © 2018 Severyanova LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
Open Access Journals
- Total views: 1988
- [From(publication date): 0-2018 - Jul 27, 2021]
- Breakdown by view type
- HTML page views: 1868
- PDF downloads: 120