alexa Inhibitory Potential of <em>Yucca Gloriosa</em> L. Extract and Isolated Gloriosaol Isomeric Mixture on Ovalbumin Induced Airway Hyperresponsiveness in Balb/C Mice | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Research Article

Inhibitory Potential of Yucca Gloriosa L. Extract and Isolated Gloriosaol Isomeric Mixture on Ovalbumin Induced Airway Hyperresponsiveness in Balb/C Mice

Saurabh Gupta1*, Basavan Duraiswamy2, Satish Kumar Muthureddy Nataraj2, Rama Satyanarayana Raju K2, Babu UV3, Sharath Kumar LM3, Omji Porwal4, and Renu Gupta5
1 Department of Pharmacology, Indore institute of Pharmacy, M.P, India
2 Department of Pharmacology and Pharmacognosy, J.S.S. College of Pharmacy, TN, India
3 The Himalaya Drug Company, Makali, Bangalore, India
4 National Institute of Pharmaceutical Education and Research (NIPER-A), Ahmedabad, India
5 Dr. Batra’s, Nirala Bazaar, Aurangabad, India
Corresponding Author : Saurabh Gupta
Associate Professor
Department of Pharmacology
Indore institute of Pharmacy Pithampur road
Opp. IIM, Rau, Indore (M.P.) 453331, India
Tel: +919407178028
E-mail: [email protected]
Received January 20, 2014; Accepted February 21, 2014; Published February 24, 2014
Citation: Gupta S, Duraiswamy B, Muthureddy Nataraj SK, Rama Satyanarayana Raju K, Babu UV, et al. (2014) Inhibitory Potential of Yucca Gloriosa L. Extract and Isolated Gloriosaol Isomeric Mixture on Ovalbumin Induced Airway Hyperresponsiveness in Balb/C Mice. Clin Pharmacol Biopharm S2:002. doi:10.4172/2167-065X.S2-002
Copyright: © 2014 Gupta S, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Yucca gloriosa (Agavaceae) is used in Indian traditional medicine as an antiallergic drug. The ethanol extract was prepared with aerial parts of Yucca gloriosa (YGE). Gloriosaol isomeric mixtures (GLM) are isolated from the extract, structurally confirmed FIA-MS/MS. Both YGE and GLM are evaluated against ovalbumin-induced airway hyperresponsiveness (AHR) in Balb/C mice. The test drugs (GLM or YGE or Dexamethasone) are administered p.o. prior to challenge with aerosolized 2.5% w/v ovalbumin. Total and differential leucocytes count, Nitrite (NO2), Nitrate (NO3), Tumor necrosis factor- α (TNF-α), Interlukin-6 (IL-6), and Interlukin-13 (IL-13) are estimated in bronchoalveolar lavage fluid (BALF). Similarly, Myeloperoxidase (MPO) and Malonaldehyde (MDA) are estimated in lungs. The results reveal a significant increase in total and differential leucocytes counts, NO2, NO3, TNF-α, IL-6, and IL-13 in ovalbumin induced AHR. However, these parameters are significantly decreased in YGE and GLM treated mice at test doses (YGE 100 & 200 mg/kg and GLM 30 mg/kg). Similar observations are recorded for Myeloperoxidase (MPO) and Malonaldehyde (MDA) in lungs. Pro inflammatory mediators are (TNF-α, IL-6, and IL-13) known that responsible for AHR. Histopathology reveled justify the effectiveness. The present investigations suggest both YGE and GLM are interesting molecules for the further research the treatment of asthma, with an approach through pro-inflammatory inhibitory pathway.

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