alexa Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by and#195;and#381;and#194;and#178;-amyloid peptide25-35 in mice: Implication of lipid peroxidation | Abstract
ISSN: 2375-4338

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Research Article

Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by β-amyloid peptide25-35 in mice: Implication of lipid peroxidation

Takayoshi Mamiya1*, Makoto Ukai1, Keiko Morikawa2 and Mitsuo Kise2
1Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Japan
2FANCL Institute, FANCL Corporation, 12-13 Kamishinano, Japan
Corresponding Author : Takayoshi Mamiya
Department of Chemical Pharmacology
Graduate School of Pharmacy, Meijo University, Japan
Tel: +81-52-839-2737
Fax: +81-52-834-8090
E-mail: [email protected]
Received October 28, 2013; Accepted November 29, 2013; Published December 02, 2013
Citation: Mamiya T, Ukai M, Morikawa K, Kise M (2013) Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by β-amyloid peptide25-35 in mice: Implication of lipid peroxidation. J Rice Res 1:116. doi: 10.4172/jrr.1000116
Copyright: © 2013 Mamiya T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

In this study, we investigated whether the food pellets containing pre-germinated brown rice (PGBR; hatsuga genmai in Japanese) were effective on the impairments of cognitive function induced by ß-amyloid peptide25-35 (Aß25-35) in mice. To evaluate the effects of PGBR, mice were received AIN-93G (as control pellets) or PGBR-added food pellets (PGBR pellets) during this study. Aß25-35 (3 nmol/3 ßmol i.c.v.) was injected to mice on the day 22. On the days 30 and 31, we assessed the tasks related to visible cognition using novel object recognition tests. By the injection of Aß25-35 in the control pellets-fed mice impairments were observed, but the mice fed PGBR-added food pellets did not show the deficits. After the behavioral tests, we found Aß25-35 increased lipid peroxidation in the hippocampus of control pellets-fed mice but not PGBR pellets-fed mice. Taken together, these results suggest that continuous feeding of food pellets containing PGBR (i) attenuates the Aß25-35-induced impairments of cognitive function, and (ii) inhibited increases in lipid peroxidation in the hippocampus.

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