Is Achieving Undetectable Viral Load in the CNS Reservoir an Important Benchmark for Curing HIV Infection?
Rajnish S Dave* and Dianne Langford
Center for Neurovirology, Department of Neuroscience, Temple University, MERB 3500 North Broad Street, Philadelphia, PA 19140, USA
- Corresponding Author:
- Rajnish S Dave
Center for Neurovirology, Department of Neuroscience
Temple University, MERB 3500 North Broad Street
Philadelphia, PA 19140 USA
Tel: (215) 707-3150
Fax: (215) 707-4888
E-mail: [email protected]
Received Date: December 20, 2013; Accepted Date: December 20, 2013; Published Date: December 28, 2013
Citation: Dave RS, Langford D (2013) Is Achieving Undetectable Viral Load in the CNS Reservoir an Important Benchmark for Curing HIV Infection? Epidemiol 4:e114. doi:10.4172/2161-1165.1000e114
Copyright: © 2013 Dave RS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Viral reservoirs present a formidable challenge in our search for a cure of human immunodeficiency Virus (HIV) infection. It is widely known tthat combined antiretroviral medications do not access the central nervous system (CNS) at optimal levels. Recent experience with hematopoietic stem cell transplant technology highlight both the need to purge the CNS reservoir from latent HIV-infected macrophages and microglia, and the requirement for utilizing homozygous CCR5Δ32 allele in successfully curing HIV infection and progression to acquired immunodeficiency syndrome (AIDS). These developments bring into focus the need to study additional alleles that affect disease progression, neurocognitive status, and potential viral egress from the CNS.