alexa Isolation and Identification of A Novel Aporphine Alkaloid SSV, An Antitumor Antibiotic from Fermented Broth of Marine Associated Streptomyces sp. KS1908 | Abstract
ISSN: 2155-9910

Journal of Marine Science: Research & Development
Open Access

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Research Article

Isolation and Identification of A Novel Aporphine Alkaloid SSV, An Antitumor Antibiotic from Fermented Broth of Marine Associated Streptomyces sp. KS1908

Sunanda Kadiri1*, Nagendra Sastry Yarla2 and Siddaiah Vidavalur1

1Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, 530 003, India

2Department of Biochemistry and Bioinformatics, School of Life Sciences, Institute of Science, GITAM University, Visakhapatnam, 530045, India

*Corresponding Author:
Sunanda Kadiri
Department of Organic Chemistry and FDW
Andhra University, Visakhapatnam
530 003, India
Tel: +91-0891-2844683
Fax: +91-0891-2525611
E-mail: [email protected]

Received date: September 26, 2013; Accepted date: October 24, 2013; Published date: October 29, 2013

Citation: Kadiri S, Yarla NS, Vidavalur S, Duddukuri GR (2013) Isolation and Identification of A Novel Aporphine Alkaloid SSV, An Novel Antitumor Antibiotic from Fermented Broth of Marine Associated Streptomyces sp. KS1908. J Marine Sci Res Dev 3:137. doi: 10.4172/2155-9910.1000137

Copyright: © 2013 Kadiri S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A marine actinomycete, Streptomyces sp. KS1908 was isolated from a marine sediment sample collected in
the Bay of Bengal, India and identified based on morphological, cultural, physiological, biochemical characteristics,along with the cell wall analysis and 16S rRNA gene sequence analysis. Strain KS1908 has more similarities with Streptomyces albus but some variations were observed. A novel aporphine alkaloid SSV was isolated according to bioactivity guided fractionation of fermented broth through solvent extraction and chromatography. Chemical structure of the aporphine alkaloid SSV was elucidated on the basis of spectroscopic analysis, including two-dimensional (2D) NMR and HR-ESI-MS data. Aporphine alkaloid SSV showed significant antibacterial, antifungal activity and also possesses considerable anticancer activity against human larynx (HEp-2), cervical (HeLa), leukemia HL-60 and MCF-7 breast cancer cell lines.

Keywords

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