alexa Leptin and Adiponectin Levels in Idiopathic Pulmonary Fibrosis: Association with Hypoxia
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Leptin and Adiponectin Levels in Idiopathic Pulmonary Fibrosis: Association with Hypoxia

Foteini Malli1, Panagiotis Georgoulias2, Varvara Valotassiou2, Fotini Bardaka1, Irene Tsilioni1,3, Konstantinos I Gourgoulianis1 and Zoe Daniil1,*
1Respiratory Medicine Department, University of Thessaly, School of Medicine, Larissa, Greece
2Nuclear Medicine Department, University of Thessaly, Larissa, Greece
3Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
Corresponding Author : Zoe Daniil
University Hospital of Larissa
Respiratory Medicine Department
Mezourlo (Biopolis), 41110, Larissa, Greece
Tel: +30 241 3502898
Fax: +30 241 3501563
E-mail: [email protected]
Received: Octomber 25, 2015;Accepted: December 1, 2015;Published: December 5, 2015
Citation: Malli F, Georgoulias P, Valotassiou V, Bardaka F, Tsilioni I, et al. (2015) Leptin and Adiponectin Levels in Idiopathic Pulmonary Fibrosis:
Association with Hypoxia. J Obes Weight Loss Ther 5:284. doi:10.4172/2165-7904.1000284
Copyright:© 2015 Malli F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
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Abstract

Background: Studies in the literature suggest a regulatory role of leptin and adiponectin in the development of fibrosis in various organs. However, their role in idiopathic pulmonary fibrosis (IPF) has not been examined in the past. The study aimed to assess the levels of leptin and adiponectin in IPF patients and 22 controls. Methods: Leptin and adiponectin were measured in serum while leptin was assessed in broncholaveloar lavage fluid and exhaled breath condensate of IPF patients. The association of the adipokines levels with markers of disease severity was also addressed. Results: Leptin levels adjusted for BMI and leptin to adiponectin (L/A) ratio in male patients with PaO2 <65 were significantly reduced as compared to male patients with PaO2 ≥65 mmHg. L/A ratio was positively associated with PaO2. Additionally, L/A ratio were positively associated with Saint George Respiratory Questionnaire components. Interestingly, exhaled breath condensate and bronchoalveolar lavage fluid leptin were not associated with corresponding serum leptin levels. Discussion: Overall our findings suggest a possible role of leptin and adiponectin in the severity and/or pathogenesis of IPF. Further studies are required in order to clarify the mechanisms and physiological relevance of our observations.

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