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Macromolecular Design of Platinum Drug Conjugates
| Neli Koseva* | |
| Institute of Polymers, Bulgarian Academy of Sciences, Bulgaria | |
| Corresponding Author : | Neli Koseva Institute of Polymers Bulgarian Academy of Sciences Acad. Georgi Bonchev Str., Bl. 103 A 1113 Sofia, Bulgaria Tel: +35929796630 E-mail: koseva@polymer.bas.bg |
| Received March 27, 2014; Accepted April 30, 2014; Published May 02, 2014 | |
| Citation: Koseva N (2014) Macromolecular Design of Platinum Drug Conjugates. Clin Pharmacol Biopharm S2:006. doi:10.4172/2167-065X.S2-006 | |
| Copyright: © 2014 Koseva N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.
