alexa Macromolecular Design of Platinum Drug Conjugates | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Macromolecular Design of Platinum Drug Conjugates

Neli Koseva*
Institute of Polymers, Bulgarian Academy of Sciences, Bulgaria
Corresponding Author : Neli Koseva
Institute of Polymers
Bulgarian Academy of Sciences
Acad. Georgi Bonchev Str., Bl. 103 A
1113 Sofia, Bulgaria
Tel: +35929796630
E-mail: [email protected]
Received March 27, 2014; Accepted April 30, 2014; Published May 02, 2014
Citation: Koseva N (2014) Macromolecular Design of Platinum Drug Conjugates. Clin Pharmacol Biopharm S2:006. doi:10.4172/2167-065X.S2-006
Copyright: © 2014 Koseva N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.

Recommended Conferences
Share This Page
Top