Macromolecular Design of Platinum Drug Conjugates | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Short Communication

Macromolecular Design of Platinum Drug Conjugates

Neli Koseva*
Institute of Polymers, Bulgarian Academy of Sciences, Bulgaria
Corresponding Author : Neli Koseva
Institute of Polymers
Bulgarian Academy of Sciences
Acad. Georgi Bonchev Str., Bl. 103 A
1113 Sofia, Bulgaria
Tel: +35929796630
E-mail: [email protected]
Received March 27, 2014; Accepted April 30, 2014; Published May 02, 2014
Citation: Koseva N (2014) Macromolecular Design of Platinum Drug Conjugates. Clin Pharmacol Biopharm S2:006. doi:10.4172/2167-065X.S2-006
Copyright: © 2014 Koseva N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cisplatin and its analogues display common drawbacks such as unfavorable toxicological profile, short blood circulation time and non-specific bio-distribution. Besides that, in biological fluids cisplatin is inactivated by nitrogenand sulphur-containing biomolecules. Drug conjugation to a water soluble polymer is a feasible approach to enhance therapeutic efficiency. Examples of carboxylate-containing polymer carriers of cisplatin and the effect of macromolecular architecture on the behavior of conjugates are discussed.