Miracle Remedy: Inhibition of Bacterial Efflux Pumps by Natural Products | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Miracle Remedy: Inhibition of Bacterial Efflux Pumps by Natural Products

Maryam Sana*, Hassan Jameel and Moazur Rahman
National Institute for Biotechnology and Genetic Engineering, Faisalabad, 38000, Pakistan
Corresponding Author : Maryam Sana
National Institute for Biotechnology and Genetic Engineering
Faisalabad, 38000, Pakistan
Tel: 251-111-239706
E-mail: [email protected]
Received March 23, 2015; Accepted April 24, 2015; Published April 30, 2015
Citation: Sana M, Jameel H, Rahman M (2015) Miracle Remedy: Inhibition of Bacterial Efflux Pumps by Natural Products. J Infect Dis Ther 3:213. doi:10.4172/2332-0877.1000213
Copyright: © 2015 Sana M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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The emergence of multidrug resistance among bacteria is a burning issue nowadays, and demanded for the discovery of the potential chemicals to deal with that resistance problem. Among several mechanisms of acquiring resistance, the over-expression of efflux pumps is very important. Efflux pumps can efflux out a large number of structurally unrelated drugs making them ineffective, which illustrates the importance of efflux pump inhibitors. Here we review the literature on efflux pump inhibitors (EPIs) from the plant sources, which will help to regain the activity of the existing antibiotics. The discovery of the new classes of natural EPIs demands further studies to explore their potential to work in synergy with existing antibiotics.


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