Nutritional Weight Loss Therapy with Cooked Bean Powders Regulates Serum Lipids and Biochemical Analytes in Overweight and Obese Dogs
|Genevieve M. Forster1, Cadie A. Ollila1, Jenna H. Burton1, Dale Hill2, John E. Bauer3, Ann M. Hess4, Elizabeth P. Ryan1*|
|1Department of Clinical Sciences, Animal Cancer Center, Colorado State University, Fort Collins 80523, USA|
|2ADM Alliance Nutrition, Inc. Quincy, IL 62301, USA|
|3Intercollegiate Faculty of Nutrition, Department of Small Animal Clinical Sciences, Texas A&M University, College Station 77843, USA|
|4Department of Statistics, Colorado State University, Fort Collins 80523, USA|
|Corresponding Author :||Elizabeth P. Ryan
Department of Clinical Sciences, Animal Cancer Center
Colorado State University, Fort Collins 80523, USA
|Received August 30, 2012; Accepted September 23, 2012; Published September 25, 2012|
|Citation: Forster GM, Ollila CA, Burton JH, Hill D, Bauer JE, et al. (2012) Nutritional Weight Loss Therapy with Cooked Bean Powders Regulates Serum Lipids and Biochemical Analytes in Overweight and Obese Dogs. J Obes Wt Loss Ther 2:149 doi:10.4172/2165-7904.1000149|
|Copyright: © 2012 Forster GM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..|
Background: Emerging evidence supports that dry bean (Phaseolus vulgaris L.,) intake promotes weight loss and regulates blood lipids. Overweight and obese dogs represent a novel translational model for diet controlled evaluation of dry beans and for assessing the effects of bean intake on serum biomarkers of weight loss. Our objective was to evaluate changes in serum biomarkers associated with weight loss after four weeks of cooked navy bean or black bean powder intake (25% weight/weight) compared to an isocaloric, macro and micronutrient matched control diet in overweight/obese dogs.
Methods: Thirty client-owned, adult dogs of diverse breeds were randomized to 1 of 3 dietary study groups at the Colorado State University Veterinary Teaching Hospital. Body weights were measured weekly and a blood serum chemistry panel was performed at baseline and 2 and 4 weeks post intervention.
Results: Average percent weight lost after 4 weeks for dogs consuming the control diet was 4.20% (± 0.88), 5.22% (± 0.91) for dogs consuming the black bean diet, and 6.52% (± 0.95) for dogs consuming the navy bean diet. Serum cholesterol decreased by an average of 17 mg/ml (P<0.02) in the control group, 40 mg/dl (P<0.001) in black bean group, and 54 mg/dl (P<0.001) in the navy bean group. Triglycerides, high-density lipoprotein, and lowdensity lipoprotein were also changed in bean groups compared to control. Furthermore, serum blood urea nitrogen was decreased in the navy bean group, creatinine was increased in both bean groups, alkaline phosphatase was decreased in the black bean group, and total protein, aspartate aminotransferase, and total bilirubin were decreased in the control group at 4 weeks compared to baseline.
Conclusion: Overweight and obese canines represent an advanced translational model and dietary bean intake regulates lipid metabolism in overweight and obese dogs.