alexa Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Research Article

Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product

Hari Krishna E1*, Rama Mohan Gupta V2 and Jyothi S1
1Department of Pharmaceutics, CES College of Pharmacy, Kurnool, India
2Principal, Pulla Reddy Institute of Pharmacy, Dommadugu, Dundigal, Hyderabad, India
Corresponding Author : Hari Krishna E
Associate Professor
CES College of Pharmacy
Kurnool-18, India
Tel: 919948904629
E-mail: [email protected]
Received January 08, 2013; Accepted January 28, 2013; Published February 01, 2013
Citation: Hari Krishna E, Rama Mohan Gupta V, Jyothi S (2013) Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product. Clinic Pharmacol Biopharm 2:107. doi:10.4172/2167-065X.1000107
Copyright: © 2013 Hari Krishna E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pharmacokinetic parameters including AUC0-t, AUC0-∝, Cmax, Tmax, T1/2 and Elimination rate constant (Kel) were determined from plasma concentrations of Zaltoprofen spherical agglomerated dense compacts by 24 factorial design canvassed with a commercially available formulation of Zaltoprofen. Foremost spherical agglomerates of Zaltoprofen prepared with PEG 6000 which is hydrophilic polymer and evaluated for different compressibility parameters and in vitro dissolution studies, studies indicated that the drug release can be modulated by using hydrophilic polymers and the best one compressed as dense compacts and appraised for pharmacokinetic parameters in rabbit models. Sensitive and selective high performance liquid chromatographic method was used to determine drug plasma concentrations with good linearity in the range of 0.5 to 20 μg/mL (r2=0.995, n=7). Study ascertained meliorated values of AUC0-24 (15.789 ± 12.9, 97.334 ± 7.478).

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