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Repeated Assessment of Exercise Capacity under Goal-Oriented Sequential Combination Therapy for Pulmonary Arterial Hypertension | OMICS International| Abstract
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Journal of Cardiac and Pulmonary Rehabilitation
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  • J Card Pulm Rehabil 2017, Vol 1(1): 103

Repeated Assessment of Exercise Capacity under Goal-Oriented Sequential Combination Therapy for Pulmonary Arterial Hypertension

Hirashiki A1,2*, Shimizu A2, Toba K2, Murohara T1 and Kondo T3
1Department of Cardiology, Nagoya University Graduate School of Medicine, , Nagoya 466-8560, Japan
2Department of Cardiology, National Center for Geriatrics and Gerontology, , Obu 474-8511, Japan
3Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine, , Nagoya 466-8560, Japan
*Corresponding Author : Hirashiki A, Department of Cardiology, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi,474-8511, Japan, Tel: +81-562-46-2311, Fax: +81-562-46-2373, Email: [email protected]

Received Date: Apr 17, 2017 / Accepted Date: Apr 27, 2017 / Published Date: May 05, 2017

Abstract

Little is known about the effects of sequential combination therapy on exercise capacity in pulmonary arterial hypertension (PAH). We monitored exercise capacity by cardiopulmonary exercise testing (CPX) and observed the benefit of using a peak oxygen uptake (VO2) cut-off of 15 mL/min/kg to guide combination therapy. The patients underwent CPX at baseline and after 3, 6, and 12 months. In patients newly diagnosed with PAH, exercise capacity progressively improved due to sequential combination therapy that was revised according to patients’ peak VO2. Therefore, repeated CPX assessment can provide useful information regarding the effectiveness of goal-oriented treatment for PAH.

Keywords: Sequential combination therapy, Cardiopulmonary exercise testing, Pulmonary arterial hypertension

Citation: Hirashiki A, Shimizu A, Toba K, Murohara T, Kondo T (2017) Repeated Assessment of Exercise Capacity under Goal-Oriented Sequential Combination Therapy for Pulmonary Arterial Hypertension. J Card Pulm Rehabil 1: 103.

Copyright: © 2017 Hirashiki A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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