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Hindi Review Article
Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia
| Satoru Yamagishi*, Sumiko Mikawa, Hiromu Furukawa, Takeshi Sasaki, Takeshi Ito, Takatoshi Ueki and Kohji Sato | |
| Department of Anatomy & Neuroscience, Hamamatsu University School of Medicine, Japan | |
| Corresponding Author : | Satoru Yamagishi Department of Anatomy & Neuroscience Hamamatsu University School of Medicine 1-20-1 Handayama, Higashiku Hamamatsu, Shizuoka 431-3192, Japan Tel: +81-53-435-2290 Fax: +81-53-435-2290 E-mail: yamagish@hama-med.ac.jp |
| Received September 13, 2012; Accepted October 06, 2012; Published October 12, 2012 | |
| Citation: Yamagishi S, Mikawa S, Furukawa H, Sasaki T, Ito T, et al. (2012) Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia. Clin Pharmacol Biopharm. S1:001. doi:10.4172/2167-065X.S1-001 | |
| Copyright: © 2012 Yamagishi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Schizophrenia is a complex disorder with positive, negative and cognitive deficits. Previously, great reduction in spine number has been reported in schizophrenia patients. Mutations in numerous genes that encode synaptic proteins are known as genetic risk factors. In addition, antipsychotic drugs change the number of spines, suggesting that disturbance in spine homeostasis is deeply involved in the pathogenesis of schizophrenia. On the other hand, abnormal release of dopamine is also reported to play a role in the disease. However, the relationship between the spine homeostasis and the dopaminergic system is largely unknown. Here, we review the related articles that can give us useful insight about spine homeostasis in schizophrenia. We hypothesize that the treatment for spine homeostasis can be a novel therapeutic method for schizophrenia.
