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Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

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Review Article

Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia

Satoru Yamagishi*, Sumiko Mikawa, Hiromu Furukawa, Takeshi Sasaki, Takeshi Ito, Takatoshi Ueki and Kohji Sato
Department of Anatomy & Neuroscience, Hamamatsu University School of Medicine, Japan
Corresponding Author : Satoru Yamagishi
Department of Anatomy & Neuroscience
Hamamatsu University School of Medicine
1-20-1 Handayama, Higashiku
Hamamatsu, Shizuoka 431-3192, Japan
Tel: +81-53-435-2290
Fax: +81-53-435-2290
E-mail: [email protected]
Received September 13, 2012; Accepted October 06, 2012; Published October 12, 2012
Citation: Yamagishi S, Mikawa S, Furukawa H, Sasaki T, Ito T, et al. (2012) Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia. Clin Pharmacol Biopharm. S1:001. doi:10.4172/2167-065X.S1-001
Copyright: © 2012 Yamagishi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Schizophrenia is a complex disorder with positive, negative and cognitive deficits. Previously, great reduction in spine number has been reported in schizophrenia patients. Mutations in numerous genes that encode synaptic proteins are known as genetic risk factors. In addition, antipsychotic drugs change the number of spines, suggesting that disturbance in spine homeostasis is deeply involved in the pathogenesis of schizophrenia. On the other hand, abnormal release of dopamine is also reported to play a role in the disease. However, the relationship between the spine homeostasis and the dopaminergic system is largely unknown. Here, we review the related articles that can give us useful insight about spine homeostasis in schizophrenia. We hypothesize that the treatment for spine homeostasis can be a novel therapeutic method for schizophrenia.