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Stem Cell-Derived Neurons for the Treatment of Neurodegenerative Diseases | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
Open Access

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Review Article

Stem Cell-Derived Neurons for the Treatment of Neurodegenerative Diseases

Haigang Gu*
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Corresponding Author : Haigang Gu
Department of Pharmacology
Vanderbilt University School of Medicine
Nashville, TN 37232, USA
Tel: 615-343-6890
Fax: 615-343-6532
E-mail: [email protected]
Received April 29, 2013; Accepted June 03, 2013; Published June 05, 2013
Citation: Gu H (2013) Stem Cell-Derived Neurons for the Treatment of Neurodegenerative Diseases. Clin Pharmacol Biopharm 2:111. doi:10.4172/2167-065X.1000111
Copyright: © 2013 Gu H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Neurodegenerative diseases are termed for the age-related chronic and progressive loss of structure and function of neurons. Most common neurodegenerative diseases include Alzheimer’s disease (AD) and Parkinson’s disease (PD). So far, no drugs can be used to reverse the neuronal degeneration. Recent progresses in stem cells biology and technology allow us to generate specific types of neurons, such as cholinergic and dopamine neurons from stem cells, with defined culture conditions. These stem cell-derived neurons have been used for cell replacement therapy in animal models of neurodegenerative neurons, such as AD and PD. Here, I summarized recent progresses of stem cell-derived cholinergic and dopamine neurons and their applications in AD and PD.