The Correlation between Overweight and Obesity with Plasma Levels of Leptin, Insulin and SdLDL in People Over 20 Years Old
|Aazam Najmafshar1, Mohsen Chiani2*, Arash Hossein Nezhad3, Sadraddin Kalantari1, Saeideh Mazloom zadeh1 and Ali Osat Mellati1|
|1Research Center of Endocrinology and Metabolism Diseases, Medical Science University of Zanjan, Zanjan, Iran|
|2Pilot Biotechnology Department, Pasteur Institute of Iran, Tehran, Iran|
|3Endocrinology and Metabolism Research center, Dr. Shariati Hospital, Medical University of Tehran, Tehran, Iran|
|Corresponding Author :||Mohsen Chiani
Pilot Nanobiotechnology Department
Pasteur Institute of Iran, No 358, 12 Farvardin Street
Jomhoori Avenue, Tehran, Iran
|Received September 22, 2012; Accepted October 22, 2012; Published October 26, 2012|
|Citation: Najmafshar A, Chiani M, Nezhad AH, Kalantari S, zadeh SM, et al. (2012) The Correlation between Overweight and Obesity with Plasma Levels of Leptin, Insulin and SdLDL in People Over 20 Years Old. J Obes Wt Loss Ther 2:150. doi:10.4172/2165-7904.1000150|
|Copyright: © 2012 Najmafshar A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
The aim of this study was to co-analysis of sdLDL, leptin and insulin at a time and their association with overweight.
This experiment was performed as a case-control on normal people visited Bu-Ali Hospital of Zanjan. Two hundred and thirteen individuals over 20 years old were analyzed totally from which 122 individuals with BMI ≥ 25 and 91 individuals with BMI<25 were assigned as case and control groups respectively. Height, weight, blood pressure and waist circumference of all individuals were measured. The quantitative measurement of the plasma level of leptin and insulin were performed with the ELISA method and the measurement of sdLDL was accomplished with the column method (sdLDL-C SEIKEN Kit from DENKA SEIKEN CO., LTD., Tokyo, Japan). The plasma level of glucose, triglycerides, cholesterol and HDL were measured enzymatically.
Among all variables, only triglycerides and waist circumference were independently associated with overweight and the effect of other variables were not independently associated with overweight, although it showed direct association with Body Mass Index. It seems that the correlation of other factors such as sdLDL, leptin and insulin with overweight is dependent to sex and age.
Our findings showed that each of these factors were correlated with the Body Mass Index; however, the logistic regression analysis revealed that age, sex, triglycerides and waist circumference are independently associated with overweight.