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The Development, Evaluation and In Vitro Release Study of the Terbinafine Transdermal Patch | OMICS International | Abstract
ISSN: 2469-9764

Industrial Chemistry
Open Access

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Research Article

The Development, Evaluation and In Vitro Release Study of the Terbinafine Transdermal Patch

Vikas G Rajurkar1*, Sambhaji Zarekar1, Vilas B Ghawate1 and Inayat B Pathan2

1Department of Quality Assurance, MES’s College of Pharmacy, Affiliated to Savitribai Phule Pune University, Sonai, Ahmednagar District, Maharashtra, India

2Department of Quality Assurance, Government College of Pharmacy, Aurangabad, Maharashtra, India

*Corresponding Author:
Rajurkar VG, Professor
Department of Quality Assurance
MES’s College of Pharmacy, Sonai-414 105
Taluka - Newasa, District - Ahmednagar
Maharashtra, India
Tel: +919860482926
E-mail: [email protected]

Received date: October 01, 2015; Accepted date: October 23, 2015; Published date: October 30, 2015

Citation: Rajurkar VG, Zarekar S, Ghawate VB, Pathan IB (2015) The Development Evaluation and In Vitro Release Study of the Terbinafine Transdermal Patch. Ind Chem Open Access 3:107. doi: 10.4172/2469-9764.1000107

Copyright: © 2015 Rajurkar VG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Transdermal drug delivery is an alternative route for systemic drug delivery, which minimizes the absorption and increase the bioavailability. Orally Terbinafine undergoes extensive metabolism and frequent high doses are required to maintain the therapeutic level as a result, dose development toxic effect. The purpose of this research work was to formulation and evaluation of transdermal drug delivery system of Terbinafine using various polymers such as HPMC E25, Eudragit-RS100 and PVP K25 with different proportions by solvent evaporation technique. The Fourier transform infrared study revealed no physical or chemical interactions between Terbinafine and excipients. The prepared formulations were evaluated for different physicochemical characteristics such as thickness, folding endurance, drug content, percentage moisture absorption, and percentage moisture loss. The diffusion studies were performed by using modified Franz diffusion cells. The result of dissolution studies shows that formulation, SA12 showed maximum release of 92.56% in 06 h, whereas SA22 showed minimum release of 45.89% in 06 h. Based on the drug release and physicochemical values obtained the formulation SA 12 is considered as an optimized formulation, which shows higher percentage of drug release.

Keywords

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