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ISSN: 2090-4967

Biosensors Journal
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Research Article

The Development of an At-Risk Biosensor for Cardiovascular Disease

Sandra Ivonne Gonzalez1 and Jeffrey T. La Belle2*

1Department of Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721, USA

2Harrington Biomedical Engineering Program, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA

*Corresponding Author:
Jeffrey T. La Belle
E-mail: [email protected]

Received date: 27 July 2012; Revised date: 29 September 2012; Accepted date: 13 October 2012

Abstract

Cardiovascular disease (CVD) is a leading cause of death worldwide. Several biomarkers have been found useful in diagnosis and management of CVD, so there is an enormous potential utility for a point-of-care biosensor capable of measuring the entire panel of CVD biomarkers on demand. This paper presents one potential component of such a biosensor, in the form of an electrochemical impedance spectroscopy (EIS)-based measurement method for one such CVD biomarker, neutrophil gelatinaseassociated lipocalin (NGAL). In this study, an antibodyfunctionalized gold disk electrode is shown to detect NGAL in blood diluted to 10% concentration, with a slope of 5.6824 ohms/LOG (ng/mL) and an R2 of 0.97 (n = 3) at 1.758 kHz. These results show the feasibility of an EISbased point-of-care biosensor for CVD markers. Future work will include expanding the method demonstrated here to cover other CVD biomarkers and integrating multiple markers into a single sensor device.

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