alexa The Dietary Supplement EGCG: NOPE(N-Oleyl- Phosphatidyletathanolamine and pigallocatechin-3-Gallato Formula)Helps Patients to Follow a Flexible Dietary Regimen and Induces Loss of Weight in Patients who had Previously Experienced No Response to Other Weight Loss Intervention | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

The Dietary Supplement EGCG: NOPE(N-Oleyl- Phosphatidyletathanolamine and pigallocatechin-3-Gallato Formula)Helps Patients to Follow a Flexible Dietary Regimen and Induces Loss of Weight in Patients who had Previously Experienced No Response to Other Weight Loss Intervention

Daniele Barbaro*, Anna Menasci, Barbara Baldini, Cristina Pasquini and Paola Lapi
Section of Endocrinology, ASL6 Livorno, Italy
Corresponding Author : Daniele Barbaro
Section of Endocrinology, ASL 6 Livorno
Viale Alfieri 36 57100 Livorno, Italy
Tel: +390586223017
Fax:+390586223380
E-mail: [email protected]
Received November 24, 2011; Accepted December 14, 2011; Published December 20, 2011
Citation: Barbaro D, Menasci A, Baldini B, Pasquini C, Lapi P (2011) The Dietary Supplement EGCG: NOPE ( N-Oleyl-Phosphatidyletathanolamine and Epigallocatechin-3-Gallato Formula) Helps Patients to Follow a Flexible Dietary Regimen and Induces Loss of Weight in Patients who had Previously Experienced No Response to Other Weight Loss Intervention. J Obes Weig los Ther 1:105. doi:10.4172/2165-7904.1000105
Copyright: © 2011 Barbaro D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and aims:Obesity is increasing in all countries. The aim of this study was that of evaluating if the treatment with the dietary supplement ( N-oleyl-phstatidylethanolamine and epigallocatechin-3-gallato formula, EGCG-NOPE) could help patients to follow a flexible dietary regimen.

Methods:38 patients (20 males, 18 females, BMI 32-41, aged 33-72 years) were enrolled consecutively. These patients were subjects who had experienced no loss of weight during an intervention program consisting of a short training period, aimed at behaviour modification, followed by a dietary program based on rules of diet, without a fixed amount of calories. These patients were instructed to take EGCG-NOPE, two capsules (EGCG 120 mg and NOPE170 mg each capsule) at 1 hour before lunch and dinner, for two months. The study had a crossover design, and after two months EGCG-NOPE was stopped, the patients continuing to follow only the prescribed dietary rules. After a further two months, patients again took EGCG-NOPE for two more months. The primary end-point of the study was weight loss and a decrease in hip circumference, while the secondary end-point involved metabolic parameters: serum glucose, Homeostasis Model Assessment (HOMA) index, serum LDL and HDL cholesterol and triglycerides.

Results: After two months of treatment with EGCG-NOPE, the weight loss was 2.42kg+/-0.3 (p<0.001), and the decrease in hip circumferences was 2.0 cm +/- 0.2 (p<0.001).There was also a decrease in serum glucose (0.083 mm/L p<0.001), HOMA index (0.48 p<0.001), serum LDL cholesterol (0.46 mm/L p< 0.01), and serum triglycerides (0.25 mm/L p<0.001). HDL cholesterol increased by 0.20 mm/L (p<0.01). Following the two months without treatment, the weight and hip circumference were steady. After the next two months of treatment, the patients had a further loss of weight (2.10 kg +/-0.4 p < 0.01) and a further decrease in hip circumference (2.0 +/- 0.1 p < 0.001).

Conclusions: EGCG-NOPE, at these doses, has shown that it is capable of decreasing the body weight and hip circumferences in patients who had failed to lose weight during a previous dietary regimen. The improvement in the metabolic parameters during treatment with EGCG-NOPE represents a further aspect of paramount importa

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