The Serotonin 2A receptor (SER 2A) Gene Polymorphism and its association with Obesity and Dyslipidemia in Semi Urban Subjects of Tamilnadu, South India | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

The Serotonin 2A receptor (SER 2A) Gene Polymorphism and its association with Obesity and Dyslipidemia in Semi Urban Subjects of Tamilnadu, South India

Shajithanoop S1, Tamilselvi periyasamy2, Rathinavel S.M3 and Usha Rani M.V1*
1Department of Environmental Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India
2Obesity Unit Kovai medical center and hospital, Coimbatore, Tamil Nadu, India
3Obesity and Diabetes Unit, A.K.P.S. Hospital, Virudhunagar, Tamil Nadu, India
Corresponding Author : Dr. Usha Rani MV
Department of Environmental Sciences
Bharathiar University
Coimbatore – 641 046, Tamil Nadu, India
E-mail: [email protected]
Received May 29, 2013; Accepted June 19, 2013; Published June 21, 2013
Citation: Shajithanoop S, Tamilselvi periyasamy, Rathinavel SM, Usha Rani MV (2013) The Serotonin Receptor 2a (Ser 2a) Gene Polymorphism and its Association with Obesity and Dyslipidemia in Semi Urban Subjects of Coimbatore, South India. J Obes Weight Loss Ther 3:178. doi:10.4172/2165-7904.1000178
Copyright: © 2013 Shajithanoop S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Serotonin is a neurotransmitter that regulates many physiological processes such as appetite, hunger, hormone secretion and sleep. Abnormalities in the serotonin transmission pathway have been implicated in obesity but no studies in Asian Indians of South India have been conducted so far. Objective: This case - control study (n=374) on semi urban subjects of Tamil Nadu, India was conducted to analyse the association of 1438 G/A polymorphism in serotonin receptor gene with obesity, dyslipidemia and smoking. Methodology: A detailed Questionnaire based interview was conducted between the years 2006 and 2011. Obese subjects (n =325) who visited the obesity unit of the hospital were recruited by purposive random sampling method, with informed and written consent. Anthropometry and clinical analysis was performed. A questionnaire based interview was adopted and Genotyping was carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: Gender wise, in obese cases, the frequency of the GG genotype (0.49) was higher in females than males. In obese males the frequency of the GA genotype (0.43) was higher than the frequencies GG genotype (0.39) and AA genotype (0.16). Furthermore, subjects with GG genotype had eight times higher risk of developing obesity (Odds ratio: 8.06, P = 0.00 & 95 % Confidence interval = 4.14 – 15.69) and subjects with GG genotype for serotonin 2A receptor had four times higher risk (Odds ratio 4.6, P = 0.000, 95% Confidence interval = 2.32 – 9.12) for developing hypertriglyceridemia. Discussion: Though the frequency of the AA genotype was comparably lower in obese cases than in controls (p<0.05), the AA genotype had a more pronounced effect on clinical factors namely BMI, WHR and TGL levels.