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The Study of Analgesic Activity of Complexes of Magnesium Sulfate with Aspirin, Paracetamol and Naproxen | OMICS International | Abstract
ISSN: 2167-065X

Clinical Pharmacology & Biopharmaceutics
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Research Article

The Study of Analgesic Activity of Complexes of Magnesium Sulfate with Aspirin, Paracetamol and Naproxen

Sangita Paul Kundu1, Md. Zakir Sultan2, Asma Rahman2, Sagar Kumar Paul3, Satabdi Shikder3, Shampa Kundu4, Md. Shah Amran1* and Md.Amjad Hossain1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000, Bangladesh
3Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka-1205, Bangladesh
4Department of Pharmacy, Bangladesh University, Mohammadpur, Dhaka-1207, Bangladesh
Corresponding Author : Md. Shah Amran
Department of Pharmaceutical Chemistry Faculty of Pharmacy
University of Dhaka, Dhaka-1000, Bangladesh
Tel: +8801718617915
Fax: +88029667222
E-mail: [email protected] du.ac.bd
Received: July 15, 2015 Accepted: August 24, 2015 Published: August 31, 2015
Citation:Kundu SP, Sultan MZ, Rahman A, Paul SK, Shikder S, et al. (2015) The Study of Analgesic Activity of Complexes of Magnesium Sulfate with Aspirin, Paracetamol and Naproxen. Clin Pharmacol Biopharm 4:143. doi:10.4172/2167-065X.1000143
Copyright: © 2015 Kundu SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The study on interaction and complexation of drug molecules with other drugs and various metal ions is an important field of research in the chemical, biochemical, medicinal and pharmacological point of views. The biological action of the drug-metal complexes may affect stability and usual activities of drugs through changing pharmacokinetic and pharmacodynamic properties. The analgesic activity was evaluated by acetic acid induced writhing test in mice. In this experiment, aspirin with magnesium sulfate at the dose of 300 mg, 600 mg and 1.5 g/60 kg body weight, Paracetamol with magnesium sulfate at the dose of 500 mg, at the dose of 1 g and of 2.5 g /60 kg body weight and Naproxen with magnesium sulfate at the dose of 500 mg, at the dose of 1 g and at the dose of 2.5 g/60 kg body weight at a ratio of 1:1, 1:2 and 2:1. It was observed that % inhibition of writhing test of all complex drug of aspirin, paracetamol and naproxen with magnesium sulfate at different ratio were less than the main drug i.e. analgesic activity were lower than the main drug. It is concluded that magnesium sulfate while formed complex as well as mixed with aspirin, paracetamol and naproxen at different ratio suppress the analgesic activity of main drug.

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