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Therapeutic Effect of Vitamin E on Testicular Tissue Damage Caused by Obesity | OMICS International | Abstract
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Research Article

Therapeutic Effect of Vitamin E on Testicular Tissue Damage Caused by Obesity

Abdullah G Al-Kushi1* , Naser A El Sawy 2,3, Hijazi M M1, Eslam A Header 4,5 and Hataba AA6

1Department of Anatomy, Faculty of Medicine, Umm al Qura University, Makkah, KSA

2Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, KSA

3Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt

4Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA

5Department of Nutrition and Food Science, Faculty of Home Economics, Minufiya University, Egypt

6Department of Chemistry, Faculty of Science, Zagazig University, Egypt

*Corresponding Author:
Abdullah G Al-Kushi
Department of Anatomy
Faculty of Medicine
Umm al Qura University
Makkah, Saudi Arabia
: 00966532570960
[email protected]

Received date: August 25, 2016; Accepted date: September 23, 2016; Published date: September 26, 2016

Citation: Al-Kushi GA, El Sawy AN, Hijazi MM, Header AE, Hataba AA (2016) Therapeutic Effect of Vitamin E on Testicular Tissue Damage Caused by Obesity. J Obes Weight Loss Ther 6:320. doi:10.4172/2165-7904.1000320

Copyright: © 2016 Al-Kushi GA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Obesity can adversely affect overall health, leading to reduced life expectancy and/or an increase in the number of health problems. Meanwhile, alterations in testicular metabolism induced by high-energy diets (HED) may induce mitochondrial dysfunction, which is closely associated to reactive oxygen species (ROS) and oxidative stress. Reactive oxygen species (ROS)-mediated damage to sperm is a significant contributing pathology in 30–80% of infertility cases. Vitamin E is considered to be the most effective liposolouble antioxidant found in biological systems. Here we evaluated the protective role of vitamin E against obesity-induced morphological changes in testes from albino rats fed different diets. Animals were divided into four groups: Group 1: standard controlled diet (SCD); Group 2: positive control group fed a high-fat diet (HFD); Group 3: αTF+HFD fed HFD supplemented with 100 mg/kg vitamin E (αTF); Group 4: αTF+SCD, fed 100 mg/kg αTF and SCD. Rats were weighed before and after the 10 week feeding period to determine changes in body weight (BWG %). After collecting blood from an intracardiac puncture under deep anesthesia, all animals were sacrificed and samples were analyzed by light microscopy. A HFD appeared to cause spermatocyte and Leydig cell damage, as well as decreases in testicular weight and function and testosterone production. Vitamin E supplementation promoted Leydig cell repair and reduced damage induced by a HFD, suggesting that vitamin E is an important dietary component to mitigate the negative effects of a high fat diet.


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