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Universal Bioanalyte Signal Amplification for Electrochemical Biosensor
Neil Gordon*
Guanine Inc., 825 N. 300 W. Suite C325, Salt Lake City, UT 84103, USA
- Corresponding Author:
- Neil Gordon
Guanine Inc., 825 N. 300 W. Suite
C325, Salt Lake City, UT 84103, USA
Tel: 1-514-813-7936
E-mail: neil.gordon@guanineinc.com
Received date: November 25, 2015; Accepted date: January 30, 2016; Published date: February 03, 2016
Citation: Gordon N (2016) Universal Bioanalyte Signal Amplification for Electrochemical Biosensor. Biosens J 4:135. doi:10.4172/2090-4967.1000135
Copyright: © 2016 Gordon N. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
A rapid, simple, and inexpensive electrochemical biosensor with guanine-conjugated microbead tags can achieve the detection limits of PCR and culturing. Guanine is a redox species that functions as an electrochemical tag for bioanalyte detection. Microbeads conjugated with guanine-rich oligonucleotides deliver millions of electrochemical tags per bioanalyte. When guanine-conjugated microbeads are used in a sandwich assay with magnetic beads and matched ligand pairs, extremely low levels of diverse bioanalytes can be electrochemically measured including microorganisms, proteins and nucleic acids.
