alexa
Reach Us +1-218-451-2974

GET THE APP

A Connectomics Approach To Investigate Mouse Models Of Neurodegenerative Diseases | 12484
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

A connectomics approach to investigate mouse models of neurodegenerative diseases

International Conference on Psychology, Autism and Alzheimers Disease

Hong-Wei Dong

ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.S1.002

Abstract
Activity of a single brain structure alone typically is not sufficient to produce behavior. Instead, behaviors require the cooperative assembly of multiple neural circuits and networks. Therefore, in disease states, both individual structures and their projection sources and targets are affected. Such ?connectopathies? have been implicated in neurological disorders such as Alzheimer?s Disease (AD). However, currently little is known about the neuroanatomical wiring in neurological disease models and how these pathological connections correspond to cognitive deficits. To address this question, our research group adopted a high-throughput connectomics approach to systematically characterize the early and advanced alterations of hippocampalsubicular neuronal networks in a mouse model of AD, which expresses nonmutant human Tau isoforms in the absence of mouse Tau isoforms (htau mice). We found that across the progression of the disease, compromised connections correlated with neuropathological hallmarks (i.e., neurofibrillary tangle) and cognitive-behavioral impairments in a hippocampal dependent contextual fear conditioning procedure. We hope our approach will provide a novel strategy for exploring diagnostic and prognostic fingerprints not only for AD, but also for other disconnection syndromes.
Biography
Top