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AD Plaques In Retina | 22042
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
Open Access
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Objective: To demonstrate AD plaques in retina. It has been suggested that Beta amyloid starts to accumulate in the retina even
before it affects the brain. Some studies even showed amyloid depositions in regions close to age related macular degeneration.
Methods: We examined 25 patients with a family history of AD and mild cognitive defects. In the patients in whom we found
hyper or hypo fluorescent lesions on FAF, OCT was performed through these regions to reveal depositions in the ganglion and
nerve fibre layers. None of the patients had retinal vascular disease due to hypertension or diabetes mellitus; only drusen like
spots- dots were noticed in different parts of the retina. Defects on RPE were not taken into consideration so that AMD lesions
would be separated from the other accumulations.
Results: In 22 patiens, we were able to find abnormal deposits in the ganglion and nerve fiber
layers. We believe that these plaque- like lesions are related to neuro- degenerative disease (AD). All the patients had positive
brain PET-CT findings.
Conclusion: We stress that all the middle- aged patients who have family history of AD should have thorough medical
examinations and retina investigation may be a part of the exam. This is the first study in which AD plaques were shown in the
retinas of alive AD patients with FDA approved devices.
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