Altered Copper Metabolism As A Theranostic Biomarker In Neurodegeneration | 21907
Journal of Alzheimers Disease & Parkinsonism
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Copper is an essential nutrient element, but excess of copper is harmful. Copper homeostasis is tightly regulated by a
delicate network of copper transporters and chaperons. Wilson?s disease, or hepatolenticular degeneration, caused by
mutation of ATP7B gene is characterized by accumulation of excess copper ions in liver and brain tissues. Positron emission
tomography (PET) is a versatile tool for real-time assessment of copper fluxes in vivo noninvasively and quantitatively.
Increased accumulation of 64Cu in liver of Atp7b-/- knockout mice, a well-established mouse model of Wilson?s disease, was
demonstrated by measuring copper fluxes in vivo with PET/CT using copper-64 chloride (64CuCl2) as a radioactive tracer
(64CuCl2-PET/CT). Age-dependent increase of 64Cu radioactivity was detected in the brain of Atp7b-/- knockout mice at 20
weeks of age compared with 64Cu radioactivity in the brains of Atp7b-/- knockout mice at 6 to 12 weeks of age. In addition to
hepatolenticular degeneration, emerging body of evidence suggests the role of altered copper metabolism in pathophysiology
of Alzheimer?s disease (AD) and other neurodegenerative diseases. Altered copper metabolism may be a useful theranostic
biomarker for early diagnosis of AD at preclinical stage with PET/CT using 64CuCl2 as a radioactive tracer. Based on favorable
outcome of copper-modulating therapy in clinical management of the patients diagnosed with Wilson?s disease, altered copper
metabolism holds potential as a therapeutic target for copper modulating therapy of AD and other neurodegenerative disease
associated with disturbance of cerebral copper metabolism.
Fangyu Peng has graduated from Jiangxi Medical College, China, in 1982 and obtained his PhD in Medical Microbiology and Immunology from University of South
Florida, USA, in 1994. He completed his nuclear medicine residency training at University of Connecticut Health Center in 2000, and clinical fellowship in nuclear
medicine and molecular imaging at National Institutes of Health Clinical Center in 2003. He is currently Associate Professor of Radiology and Advanced Imaging
Research Center, University of Texas Southwestern Medical Center, USA. He has published more than 30 peer-reviewed articles in reputed journals and serving
as an editorial board member of Journal of Radiology and Radiation Therapy.
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