An Early Discrimination Between Normal And Pathological Brain Aging | 12539
Journal of Alzheimers Disease & Parkinsonism
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The brain as a system with gradually decreasing resources maximizes its chances by reorganizing neural networks to ensure
efficient performance. Auditory event-related potentials were recorded in 28 healthy volunteers comprising 14 young and
14 elderly subjects in auditory discrimination motor task (low frequency tone - right hand movement and high frequency tone
- left hand movement). The amplitudes of the sensory event-related potential components (N1, P2) were more pronounced with
increasing age for either tone and this effect for P2 amplitude was more pronounced in the frontal region. The latency relationship
of N1 between the groups was tone-dependent, while that of P2 was tone-independent with a prominent delay in the elderly group
over all brain regions. The amplitudes of the cognitive components (N2, P3) diminished with increasing age and the hemispheric
asymmetry of N2 (but not for P3) reduced with increasing age. Prolonged N2 latency with increasing age was widespread for
either tone while between-group difference in P3 latency was tone-dependent. High frequency tone stimulation and movement
requirements lead to P3 delay in the elderly group. The amplitude difference of the sensory components between the age groups
could be due to a general greater alertness, less expressed habituation, or decline in the ability to retreat attentional resources from
the stimuli in the elderly group. With aging, a neural circuit reorganization of the brain activity affects the cognitive processes.
The approach used in this study is useful for an early discrimination between normal and pathological brain aging for early
treatment of cognitive alterations and dementia.
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