ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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Application of LC-MS Based Methodologies for the Characterization and Quantitation of Complex Biologics- Antibody Drug Conjugates

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

Babu Subramanyam, J. Shen, J-L, Tseng, C. Elango and J-M Gu

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Abstract
Though LC-MS based platforms are an integral part of �small molecules�/ Xenobiotic drug discovery/development paradigm, application of these techniques to biologics is still an evolving field. In this paper the application of LC- MS and LC-MS/MS techniques for the characterization and quantitaion of complex biological entities such as antibody drug Conjugates (ADCs) will be discussed. The discussion will highlight how the LC-MS data can complement the more traditional ELISA based assays and what additional information can be gleaned from the MS data regarding the integrity and bioprocessing of these complex drug entities.
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