Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us
+44 1223 790975
GET THE APP
Association Of IL-6 And TNF- Gene Polymorphisms With The Risk Of Alzheimers Disease In Saudi Subjects | 101962
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Association of IL-6 and TNF- gene polymorphisms with the risk of Alzheimers disease in Saudi subjects
13th Annual Conference on Dementia and Alzheimers Disease
Reem Moteb Abdulaali Almotairi, Saba Abdi, Amani Alghamedi , Taim Muayqil, Syed Danish Hussain, Mohammed Ghouse Ahmed Ansari , Mohammed Masoud, Nasser Al-Daghri
Alzheimer�????s disease (AD) is a progressive neurodegenerative disorder and the most prevalent type of dementia. In Saudi
Arabia although the exact percent about the spread of AD has not been estimated, but the experts believe that there
are approximately 50,000 patients in Saudi Arabia, most of them being females. Many of studies illustrate the role of the
inflammation in development of AD, however no such study has been done on Saudi AD patients. Thus, the aims of this
study were to investigate the association of inflammatory mediator�????s, interleukin-6 (IL-6), Tumour necrosis factor-??� (TNF-??�)
and C-reactive protein (CRP) with increased the risk of Alzheimer�????s disease (AD). Further, the association between the level
of IL-6, TNF-??� and CRP with the genetic variation in IL-6 (-174 rs1800795 G/C and -572 rs1800796 C/G), and in TNF- ??�
(-308 rs1800629 A/G and -1031 rs1799724 C/T) and their role in occurrence of AD in among Saudi ethnic population was
investigated. A total of 47 Saudi subjects with age (65-90 years) were enrolled for the study, 24 (14 male, 10 female) diagnosed
as AD patients and 23 (11 male, 12 female) served as normal controls. The level of biomarkers (IL-6, TNF-??� and CRP) were
assessed by ELISA (Quntikine??�ELISA). Single nucleotide polymorphism (SNP) in selected genes were analyzed by RT-PCR
using Taqman assay. This study showed that TNF- ??� was higher in AD patients with CC and GC genotypes for IL-6 gene SNPs
rs1800796 (P=0.062) and rs1800795 (P=0.066) respectively. The level of IL-6 was also found to be significantly low among AD
patients with AG genotype comparing to AD patients with GG genotype for -308 A/G (rs1800629) of TNF-??� gene (P=0.040).
In conclusion; The level of inflammatory cytokines IL-6 and TNF-??� may play role in the progression of AD depending on
specific genotypes among Saudi AD patients.
Biography
Reem Almotairi is currently pursuing master’s at Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. And certified with the license of Health Professionals Classification, Under the name "Laboratory Technician", from Saudi Commission for Health Specialties.
Relevant Topics
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals