Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Reach Us +44 1223 790975


Bioinorganic Implications And Strategies In Parkinsons Disease | 58300
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

5th World Brain Congress

Rome, Italy
Google Scholar citation report
Citations : 3123

Journal of Alzheimers Disease & Parkinsonism received 3123 citations as per Google Scholar report

Journal of Alzheimers Disease & Parkinsonism peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page

Bioinorganic Implications and Strategies in Parkinsons Disease

2nd International Conference on Parkinson’s Disease & Movement Disorders

Heather R Lucas

Virginia Commonwealth University, USA

Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.C1.025

Brain metal compositions change with aging and with the progression of neurodegenerative diseases. Under oxidatively stressed conditions, redox metals can promote the generation of free radicals. Alpha-synuclein (αS), the structurally dynamic protein implicated in Parkinson’s disease (PD) pathology, has shown variable changes in its native biophysical properties in the presence of redox metals. Such metal promoted αS misfolding and/or post-translational modifications can have detrimental effects on normal function. The presented research will highlight metal-induced changes in the folding pattern of αS and the distinguishable differences observed between various metal oxidation states. The aggregation propensity of αS has been examined by circular dichroism analysis, dynamic light scattering, FT-IR, and thioflavin T fluorescence assays, as well as through immunoblotting techniques. Another avenue of this research capitalizes on these innate bioinorganic characteristics to target the dissociation of aggregation prone αS. Macrocyclic metallospecies are being utilized to proteolytically cleave αS β-sheet fibrils. Thus, the same characteristics that can make aberrant metal-promoted chemistry detrimental, have also been utilized to affect αS aggregates, as are found in PD Lewy bodies. Through this work, new therapeutic strategies for the treatment of PD and related disorders may become apparent.

Heather R. Lucas obtained her Ph.D. in 2009 at the Johns Hopkins University and subsequently carried out research at Osaka University in Japan with the support of a fellowship through the Global Center of Excellence. She was additionally a Lenfant Biomedical Fellow at the National Heart, Lung and Blood Institute and an NIH postdoctoral fellow at the National Institute on Aging. Dr. Lucas then joined the faculty within the Virginia Commonwealth University Department of Chemistry and Chemical Biology Program as an Assistant Professor for the Spring of 2014, where her research group encompasses inorganic biochemistry, biophysics, as well as inorganic and organic syntheses.