Journal of Biomimetics Biomaterials and Tissue Engineering
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The mechano-regulation algorithm using interstitial fluid velocity (FV) and octahedral shear strain (OSS) is well-accepted for
predicting normal fracture healing in a poroelastic medium (PM). However, the ability of OSS as a single bio-feedback variable
to predict the normal healing pattern in a PM is still a place of debate. This work is an attempt to check the validity of the hypothesis
that the OSS could solely regulate tissue differentiation in a PM, as well as to investigate whether or not the OSS could solely regulate
tissue differentiation in an elastic medium (EM). For this purpose, a 2D model of a broken tibia, with a 3 mm fracture gap, was made
and a biphasic finite element analysis was done to simulate bone healing process. The differentiation of stem cells and development
of tissues was implemented as a biofeedback loop by use of Python scripting in Abaqus software. In the poroelastic model, results of
this study showed that OSS could predict bone formation at the callus tip and the intramedullary canal, as well as its progress toward
intracortical gap successfully. However, it failed to predict bony bridge at the external callus and a narrow strip area was left with
fibrous tissue, which restrained completion of healing pattern. In the elastic model, OSS correctly predicted healing process, but the
completion of process occurred much faster than in normal healing. In conclusion, results of this study indicate that OSS cannot be
considered as a single regulator of tissue development in the normal fracture healing process.
Gholamreza Rouhi received his BSc and MSc degrees from Sharif University of Technology, and his PhD from the University of Calgary for his investigations on bone remodelling and resorption theories. After earning his PhD degree, he joined University of Ottawa, Canada, as Assistant Professor. He then moved back to Iran and was recruited by Amirkabir University of Technology (AUT). He is involved in various projects including: Bone fracture healing; bone remodelling theories; bone-implants interaction; orthopaedic implants and prostheses; and biomechanics of articularcartilage. He is now the Director and Principal Investigator of Orthopaedic & Dental Biomechanics Lab at AUT.
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