ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Chronic microvascular ischemia is associated with cerebral amyloid burden in patients with cognitive impairment

10th World Congress on Alzheimer's Disease & Dementia

Hae Won Kim, Hyon-Ah Yi, Kyoung Sook Won and Hyuk Won Chang

Keimyung University Dongsan Medical Center, Republic of Korea Semyung Radiology Clinic, Republic of Korea

Posters & Accepted Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460-C4-046

Abstract
Background & Purpose: White Matter Lesions (WML), detected as hyperintensities on T2-weighted magnetic resonance imaging, represent chronic microvascular ischemia in the brain and are considered potential risk factors for memory and cognitive impairment in the elderly. The purpose of this study is to evaluate the association between WML and the cerebral �?²-Amyloid (A�?²) burden in patients with cognitive impairment. Method: 19, 30 and 34 patients with subjective cognitive impairment, mild cognitive impairment and alzheimerâ�?�?s disease, respectively, who underwent brain MRI and F-18 florbetaben PET, were included. The Fazekas scale was used to quantify WML on brain T2-weighted images. The cerebral A�?² burden was quantitatively estimated using volume-of-interest analysis. The difference in Fazekas scale was evaluated between the A�?² positive and negative groups. The relationship between the Fazekas scale and the cerebral A�?² burden was evaluated using linear regression analysis after adjustment for age and sex. Result: There were no differences in age and sex among the patients with subjective cognitive impairment, mild cognitive impairment and alzheimerâ�?�?s disease. In the overall cohort and mild cognitive impairment group, A�?² positive patients exhibited significantly higher Fazekas scale compared with A�?² negative patients (0.8 vs. 1.3; P=0.024 and 0.5 vs. 1.4; P=0.022). In addition, the cerebral A�?² burden was positively correlated with the Fazekas scale (�?²=0.299; P=0.006 and �?²=0.517; P=0.003). Conclusion: WML are associated with the cerebral A�?² burden in patients with cognitive impairment. This suggests that chronic microvascular ischemia contributes to the development of alzheimerâ�?�?s disease.
Biography

Hae Won Kim is a Specialist in the Department of Nuclear Medicine at Keimyung University Dongsan Medical Center, Republic of Korea.
Email:hwkim.nm@gmail.com
 

https://bahigox.fun/ https://bahisjet.fun/ https://bahsegel.fun/ https://betboo.fun/ https://betdoksan.xyz/ https://betebetgiris.xyz/ https://betexper.fun/ https://betgram.fun/ https://betkanyon.fun/ https://betkolik.fun/
Top