alexa Clinical And Neuroimaging Heterogeneity In The Transition From Normalcy To Dementia
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Oscar L Lopez
Accepted Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.010
The incidence of dementia in the elderly, especially Alzheimer?s disease (AD) doubles every 5 years, and estimates of prevalence showed the presence of dementia in 7-8% of the individuals age 65-75 and 45% after age 85. Therefore, there are significant scientific efforts to understand the transition from normalcy to dementia, which is essential to develop primary and secondary prevention therapies. Although there are extensive data on the incidence of dementia in mild cognitive impairment (MCI) subjects, there are few data on the incidence MCI in cognitively normal subjects. Those data that do exist showed the majority of the elderly subjects after age 80 develop an MCI syndrome, and that more than half of them progressed to dementia. Because neuroimaging studies have shown that hippocampal atrophy and amyloid deposition in MCI subjects are predictors of conversion to AD, it has been suggested that MCI or normal subjects with amyloid deposition or hippocampal atrophy have a pre-AD state. However, recent studies showed that progression from normal cognition to MCI, or from normal to MCI to dementia is not always linear. In addition, there are subjects with brain atrophy or amyloid deposition who do not necessarily progress to dementia, while others can do it within a relatively short period of time. This suggested that the pathophysiology of the transition from normal to dementia is complex. There are undetermined factors that can ?accelerate? conversion from normal to dementia in patients with pre-AD pathological features, and that there are other factors that can ?protect? them from developing a clinical dementia syndrome.
Oscar L Lopez is Professor of Neurology and Psychiatry at the University of Pittsburgh, School of Medicine, Director of the Alzheimer?s disease Research Center of Pittsburgh, and Chief of the Cognitive and Behavioral Neurology Division in the Department of Neurology. His primary research interest has focused on the distribution (incidence and prevalence), behavioral manifestations, risks, and long term outcomes of dementia, especially Alzheimer?s disease, and he has published classic papers examining the patterns of progression of all clinical forms of Alzheimer?s disease. He has conducted a large scale study in the clinical diagnosis of mild cognitive impairment (MCI), and he is currently conducting studies of the factors that modulate the transition from normal to MCI and to dementia in relationship to cerebral amyloid deposition.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version