alexa Contributions Of Translational Behavioral Neuroscience To The Advanced Diagnostic And Therapeutic Approaches Towards Dementia
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Alzheimers Disease and Dementia
September 23-25, 2014 Valencia Convention Centre, Spain

Lydia Gimenez Llort
ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism
DOI: 10.4172/2161-0460.S1.006
Abstract
Clinical manifestations of Alzheimer?s disease (AD) are complex and heterogeneous, far from restricted to the progressive loss of learning and memory. Loss of judgment and executive functions together with the early appearance of Behavioral and Psychological Symptoms of Dementia [BPSD] are considered a strong source of distress and burden for the patients and caregivers. Actually, growing number of studies assessing AD therapeutic strategies targeting mnemonic effects also look for benefits on these other symptoms. At the preclinical level, behavioral neuroscience has confronted the difficulty of modeling this clinical heterogeneity in experimental animals and scarce literature examine the whole array of symptoms. The author will summarize the findings obtained in the Spanish colony of 3xTg-AD mice using a multidimensional behavioral screening approach (functional, BPSD and cognition, social) together with other levels of study (cellular, neurochemical, physiological, immunoendocrine and neuropathological). Evidence of appearance of BPSD-like symptoms were provided from premorbid and prodromal stages associated with early impairment of the neuro-immuno-endocrine network, advanced biological age and disruption of neurophysiological homeostasis. These alterations worsened with age, were gender-dependent and related to increased vulnerability and mortality. This comprehensive multidimensional behavioral screening has provided a unique tool to assess the potential preventive and/or therapeutic value of strategies based on life-style (voluntary and forced exercise), psychological stimulation (postnatal handling, environmental enrichment, family structure), pharmacological interventions (Melatonin, Huperzine A, Huprine-derivates, 5HT-4 agonists) and Ab-immunotherapy (scFv-h3D6). The contributions of behavioral neuroscience from our and other laboratories offer a promising scenario for translational research.
Biography
Lydia Gimenez Llort completed her PhD from CSIC - University of Barcelona and postdoctoral studies from Karolinska Institutet. She is Associate Professor of Psychiatry at the Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona. She is also member of the Institute of Neuroscience where she was part of the Directive board and coordinator of the Master in Neuroscience. She founded the scientific network 4the5.net and she?s member of 2009-SGR- 0051, RETICEF (RD06/0013/0003), UCM-CM ENEROINN 910379 and Neurogenet Consortium. She represents Spain at the European COST-action TD1005 ?Pain Assessment in Patients with Impaired Cognition, especially Dementia?. She has published 70 papers in reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version