Copper-A? Induced Erythrocyte Oxidative Stress And Inhibition By Polyphenolic Antioxidants | 12466
Journal of Alzheimers Disease & Parkinsonism
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Oxidative stress is a primary trigger for neuronal dysfunction and is considered a causative factor contributing to Alzheimer?s
disease (AD) and the associated loss of cognitive function. Reactive oxygen species (ROS) generated by copper-bound
amyloid-? peptide (CuA?) are also thought to contribute to AD pathogenesis since insoluble proteinaceous deposits enriched
with amyloid plaques and copper are found in AD brains. Previously, we reported that erythrocyte exposure to a partially
aggregated form of CuA? leads to a pronounced increase in red blood cell oxidative stress. These findings suggest that erythrocyte
oxidative damage, which would result in improper tissue perfusion, may be involved in the etiology of AD. Antioxidants such as
resveratrol and quercetin have been shown to incorporate into red cell membranes and increase the oxidant scavenging ability
of the cell. Thus, the ability of these antioxidants to inhibit red cell oxidative stress promoted by CuA?/ROS was investigated.
The presented work will show that oxidative reactions promoted by CuA? occur in close proximity to the red cell membrane
and that membrane incorporated antioxidants can protect erythrocytes from the accompanying oxidative stress. Mitigation of
ROS produced by CuA? through natural antioxidants from our diets may subsequently reduce vascular inflammation, cognitive
impairment, and/or neuro degeneration associated with AD.
Heather R. Lucas completed her Ph.D. at Johns Hopkins University in 2008 and conducted her postdoctoral studies at the National Institutes of
Health. She will begin as an Assistant Professor at Virginia Commonwealth University during the fall of 2013.
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