Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 1636
Journal of Gastrointestinal & Digestive System received 1636 citations as per Google Scholar report
Journal of Gastrointestinal & Digestive System peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Demethyleneberberine attenuates isoniazid-induced-liver injury by reducing CYP2E1 expression and preventing endoplasmic reticulum stress
8th International Conference on Clinical Gastroenterology & Hepatology
Lulu Xu, Xiaoyan Qiang and Yubin Zhang
China Pharmaceutical University, China Virginia Commonwealth University, USA
ScientificTracks Abstracts: J Gastrointest Dig Syst
Abstract
Introduction: With the wide clinical application of isoniazid (INH) for tuberculosis treatment, its hepatotoxicity is emerging as a most common adverse effect. Demethyleneberberine (DMB) is a natural product existing in Chinese herb, which plays an important role in protecting against liver disease. Aim: To investigate the potential effect of DMB against INH-induced liver injury by reducing CYP2E1 expression and preventing endoplasmic reticulum stress. Methods: To investigate the potential effect of DMB against INH-induced liver injury, 8-week-old male C57 mice were given INH (150 mg/kg) for 3 weeks. The mice were administrated DMB (10 and 20 mg/kg) or a positive control drug tiopronin (50 mg/kg) via enterocelia concurrently. Serum levels of aspartate aminotransferase (AST), and liver homogenate glutathione (GSH), malondialdehyde (MDA), total cholesterol (TC) and triglyceride (TG) were measured. The expression levels of CYP2E1 and ER stress associative protein were determined. Section of livers was collected for photographic and microscopic observation by hematoxylin and eosin (HE) staining. Results: DMB protected the liver function with significantly low serum AST level. Lipid-lowering effect of DMB was observed with reductions in liver TG and TC, which consisted of HE stained sections (with the observation), reflected that DMB dosedependently reversed the INH-induced-liver injury, as there were much less lipid droplets depositing inside the parenchyma cells. The benefits of DMB were associated with increased GSH and decreased MDA activity and CYP2E1 expression in the livers. Furthermore, DMB remarkably inhibited ER stress by down-regulating UPR (GRP78) and ATF4-CHOP pathway. Conclusion: DMB exerts protective effect against INH-induced-liver injury in mice, which may be associated with its regulation of lipid metabolism, reduction of CYP2E1 expression and inhibition of ER stress.Biography
Lulu Xu is an MD-PhD working at the China Pharmaceutical University, China. She has completed her Bachelor's degree from China Pharmaceutical University, China.
Email: 994516225@qq.com
