alexa
Reach Us +1 218 451 2974
Depression Predicts Imminent Conversion From Mild Cognitive Impairment To Alzheimer′s Disease | 57425
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences
Share This Page

Depression predicts imminent conversion from mild cognitive impairment to Alzheimer′s disease

5th International Conference on Alzheimer’s Disease & Dementia

Michaela Defrancesco, Georg Kemmler, W. Wolfgang Fleischhacker, Imrich Blasko and Eberhard A. Deisenhammer

Medical University of Innsbruck, Austria

ScientificTracks Abstracts: J Alzheimers Dis Parkinsonism

DOI: 10.4172/2161-0460.C1.021

Abstract
Background: Mild cognitive impairment (MCI) has been suggested to represent a prodromal stage of dementia and confers a high risk for conversion to Alzheimer´s disease (AD). In this study, we examined the predictive value of depressive symptoms and neuropsychological variables on conversion of MCI to AD. Methods: Our sample consisted of 260 MCI patients seen at the Psychiatric Memory Clinic of Innsbruck between 2005 and 2015. Neuropsychological and clincal data of the baseline and at least one follow-up visit were collected retrospectively. Depression was assessed using the Geriatric Depression Scale (GDS). Univariate and logistic regression analyses were performed. Results: Of the 260 patients (mean age 71.5±7.7 years) 83 (32%) converted to AD within a mean follow-up time of 3.2± 2.2 years. The univariate ananlysis showed higher age and GDS score and lower MMSE, verbal memory, Boston naming and Clox I test scores at baseline in converting MCI compared to stable MCI patients. However, logistic regression analysis revealed solely depression, MMSE and verbal memory scores as significant predictors of imminent conversion from MCI to AD. Conclusion: Our results support the previously reported predictive value of deficits in verbal memory and lower MMSE scores in the progression of AD. In addition, we found a strong negative influence of depression on MCI patients before imminent conversion to AD. These results emphasise the importance of depressive symptoms in early stages of AD and their possible impact on conversion from MCI to dementia stage.
Biography

Michaela Defrancesco has completed her university education in medicine and PhD in neuroscience in 2013 at the Innsbruck Medical University and finished her psychiatric residency in 2015. She is the head of the memory clinic of the psychiatric department of the University Clinic of Innsbruck. Her scientific work focuses on early signs and predictors of conversion from Mild cognitive impairment to Alzheimer´s disease.

Email: [email protected]

Top