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Development Of Polysorbate-80 Coated Galantamine Nanorticles To Treat Alzheimer?s Disease | 21950
ISSN: 2161-0460
Journal of Alzheimers Disease & Parkinsonism
Open Access
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Galantamine is an alkaloid that is used for treating mild to moderate Alzheimer?s disease. Due to the presence of blood
brain barrier, Galantamaine has very poor bioavailability to the brain. Hence, an attempt was made to develop polysorbate
80 coated galantamine nanoparticles to target brain. The nanoparticles were successfully prepared by simple ionic gelation
method using chitosanss and optimized to obtain a size under 200nm. The prepared nanoparticles were characterized for its
physiochemical properties, in vitro cytotoxicity and internalisation of nanoparticles in SH-SY-5Y human neuroblastoma cell
line. The particle size of optimized chitosan nanoparticles ranged from 116 ? 4.2 to 155 ? 3 nm and the zeta potential value
ranges from +31.2 ? 1.7 to +40 ? 1.5 mV. The drug entrapment ranged from 42.3 ? 1.6% to 70.6 ? 1.5% and in vitro drug
release values varied from 55.2 ? 2.8 to 64.5 ? 3.2 %. Cytotoxicity studies established absence of any toxicity on SH-SY-5Y
human neuroblastoma cell with the drug concentrations of 10 and 100?g/ml. Internalisation of galantamine nanoparticles in
SH-SY-5Y human neuroblastoma cell lines revealed that polysorbate-80 coated nanoparticles facilitated time depended uptake
in the human neuronal cells. In vivo pharmacokinetics and brain distribution studies revealed that the polysorbate-80 coated
nanoparticles had better brain targeting effiecncy than the uncoated nanoparticle. Hence polysorbate-80 coated chitosan
nanoparticles will be a potential carrier to target brain.
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