Differential Electrolytic Potentiometric, A Detector For SIA Determination Of Iansoprazole And Pantoprazole In Pharmaceutical Preparations | 5945
Journal of Analytical & Bioanalytical Techniques
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Differential electrolytic potentiometry (DEP) was coupled with Flow injection analysis (SIA) technique for the determination
of Lansoprazoe (LZ) and Pantoprazole (PZ) in pharmaceutical preparations.
Platinum electrodes were used as an indicating system to follow the oxidation of these drugs with permanganate in an acidic
medium. The oxidation reactions are fast enough to permit its determination by flow injection in sulfuric acid media.
The univariate method was employed to optimize the variables such as the current density, the flow rate, and the oxidant
concentration, the optimum conditions were found to be as follow: permanganate solution concentration is 6.0X10-3 M, current
density is 40 μAcm-2, and flow rate is 25 μlsec-1.
The proposed method was linear in the range 20-120 μgml-1, for LZ the DL and R2 values were 13.0 μgml-1 and 0.997
respectively, and for PZ the DL and R2 values were 11.5 μgml-1 and 0.998 respectively.
The procedure was applied successfully to the determination of the drugs in commercial tablets. The results of this study
were favorably compared statistically with those obtained from standard methods.
Safwan Fraihat has completed his Ph.D at the age of 33 years from King Fahd University. He worked in different universities as a professor and researcher, he has published more than 10 papers in reputed journals. His research interest focused on developing new analytical chemistry methods for the determination of pharmaceutical and environmental important compounds.
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